慢性肾小球肾炎患者血清肝细胞生长因子的变化及意义

Function of hepatocyte growth factor in patients with chronic glomerulo nephritis

目的:探讨血清肝细胞生长因子在慢性肾小球肾炎患者中的变化及意义。方法:应用ELISA法测定124例慢性肾小球肾炎患者及35例健康人血清肝细胞生长因子的含量,应用免疫散射比浊法同时检测其尿白蛋白含量。结果:慢性肾小球肾炎组血清肝细胞生长因子含量及尿白蛋白水平明显高于正常对照组(P<0.01);增生型肾炎组和微小病变型肾炎组血清肝细胞生长因子含量明显高于肾小球硬化型肾炎组(P<0.05);增生性肾炎组和微小病变组间肝细胞生长因子差异无统计学意义(P>0.05);经过治疗后慢性肾小球肾炎患者血清肝细胞生长因子水平有明显下降(P<0.05)。结论:测定血清肝细胞生长因子含量对慢性肾小球肾炎的诊断治疗及预后评价有一定的临床价值。

Objective：To explore the variation trend and effect of hepatocyte growth factor in patients with chronic glomerulonephritis.Methods：The serum hepatocyte growth factor level was measured by ELISA in 124 patients with chronic glomerulonephritis and 35 cases of normal control.The urinary albumin level was measured by immunonephometric assay.Results：The hepatocyte growth factor and urinary albumin level in chronic glomerulonephritis group were higher than normal contol group significantly（P〈0.01）.The hepatocyte growth factor level of proliferative nephritis group and minimal change nephrosis group were higher than sclerotic glomerulonephritis group significantly（P〈0.05）.It had no significant difference between the proliferative nephritis group and minimal change nephrosis（P〉0.05）.The hepatocyte growth factor level of chronic glomerulonephritis group decreased obviously after therapy（P〈0.05）.Conclusion：Hepatocyte growth factor has a clinical role in the diagnosis and prognosis of chronic glomerulonephritis.