院内感染亚胺培南耐药的铜绿假单胞菌的分布及耐药性分析

Distribution and antibiotics resistance analysis of hospital acquired imipenem-resistant Pseudomonas aeruginosa isolates

目的:分析哈尔滨地区亚胺培南耐药的铜绿假单胞菌的科室分布、标本来源及其耐药情况,为临床预防感染及合理用药提供依据。方法:采集各临床科室收集的标本,采用K-B法进行药敏实验。结果:亚胺培南耐药的铜绿假单胞菌以呼吸道和伤口创面分泌物为主要临床来源,其中药物敏感性最好的为阿米卡星(62%),其次为氨曲南(58%)、哌拉西林/他唑巴坦(57%)、头孢哌酮/舒巴坦(52%);庆大霉素、哌拉西林、头孢他啶、左旋氧氟沙星敏感性较低,分别为26%、34%、38%和40%,耐药率最高的是阿莫西林/棒酸(90%),其次为帕尼培南(76%)、头孢噻肟(74%)及庆大霉素(69%)。结论:亚胺培南耐药的铜绿假单胞菌常表现为多重耐药,需加强预防,降低其感染几率;并合理的使用抗生素,减少耐药株的产生。

Objective：To providing a basis of hospital infection prevention and rational use of antibiotics,the section distribution,sources and antibiotics resistance of imipenem-resistant Pseudomonas aeruginos were analyzed in Harbin area.Methods：Clinical samples were collected and K-B disc diffusion method was used for drug susceptibility tests.Results：Sputums and wound secretions were the main clinical sources of the Imipenem-resistant Pseudomonas aeruginosas.The best susceptibility was amikacin of 62%,aztreonam,piperacillin/tazobactam,cefoperazone/sulbactam of 58%,57%,52% respectively;gentamicin,piperacillin,ceftazidime,levofloxacin,showed lower susceptibility of 26%,34%,38% and 40%,respectively.While amoxicillin/clavulanic acid presented the highest resistance of 90%,panipenem,cefotaxime and gentamicin of 76%,74%,69%,respectively.Conclusions：Imipenem-resistant Pseudomonas aeruginosas usually represent multi-drug resistance,as the result strengthen prevention and rational use of antibiotics should be taken to prevent the infection and reduce drug resistance of Pseudomonas aeruginosas isolates.