新生儿败血症治疗前后降钙素原与C反应蛋白的监测及临床意义

Monitoring and significance of CRP and PCT before and after treatment in neonates with bacteriotoxemia

目的:探讨联合检测降钙素原(PCT)、C反应蛋白(CRP)水平的改变在新生儿败血症患儿治疗前后的临床意义。方法:收集治疗前后60例新生儿败血症患儿和60例非感染性对照组患儿血清,分别用免疫层析法和免疫比浊法测定血清PCT和CRP含量。结果:抗生素治疗前新生儿败血症患儿血清PCT、CRP水平明显高于对照组(P<0.01),合理抗生素治疗一周后,血清中PCT和CRP水平明显下降,与急性期比较差异有显著性意义(P<0.01)。PCT的敏感性及特异性分别为88.2%、100%;CRP的敏感性及特异性分别为89.5%、70.8%。结论:联合检测新生儿败血症患儿治疗前后PCT、CRP水平的变化可作为病情监测和疗效评价指标。

Objective：To explore the diagnostic value of serum procalcitonin and CRP in neonates with bacteriotoxemia before and after treatment.Methods：We collected serum from 60 neonates with bacteriotoxemia and 60 neonates without infection.Serum procalcitonin was determined by immunochromatography,CRP was measured with trubidimetric assay.Results：The levels of PCT and CRP in neonates with bacteriotoxemia were higher significantly than those in neonate without bacteriotoxemia（P〈0.01）.After appropriate treatment by antibiotics,PCT and CRP decreased obviously compared with those in acute period（P〈0.01）.in the meantime,we found the sensibility and specificity of PCT were 88.2% and 100% respectively,and the sensibility and specificity of CRP were 89.5% and 70.8% respectively.Conclusion：Serum procalcitonin and CRP could be used as a rapid diagnostic marker for neonates with bacteriotoxemia,and it can also evaluate infection for patients.