屎肠球菌和粪肠球菌的耐药性分析

Antibiotic resistance study of Enterococcus faecium and Enterococcus faecalis

目的:了解屎肠球菌和粪肠球菌的耐药性,为临床提供治疗依据。方法:回顾性统计分析2005年1月～2009年9月间临床分离的屎肠球菌和粪肠球菌的分布与药敏试验结果。结果:检出屎肠球菌1286株和粪肠球菌1042株,均主要分离于尿液和痰液。屎肠球菌和粪肠球菌对利奈唑胺、万古霉素、替考拉宁的耐药率≤5.0%,对利福平耐药率≥74.3%。屎肠球菌对氨苄西林、青霉素和左旋氧氟沙星的耐药率≥92.3%,而粪肠球菌对相应药物的耐药率≤22.5%。屎肠球菌对高浓度庆大霉素和呋喃妥因的耐药率亦高于粪肠球菌。只有四环素的耐药率相反。结论:屎肠球菌对大多数抗菌药物的耐药率高于粪肠球菌,已发现万古霉素耐药肠球菌,应引起重视。

Objective：To investigate the anti-microbial resistance of Enterococcus faecium and Enterococcus faecalis to provide data for anti-infection therapy.Methods：We analyzed the clinical distribution and antibiotic resistance of E.faecium and E.faecalis which were collected from January 2005 to September 2009.Results：1286 isolates of E.faecium and 1042 isolates of E.faecalis were collected,and both of them mainly isolated from urine and sputamentum.Less than 5.0% of E.faecium and E.faecalis isolates were resistant to linezolid,vancomycin and teicoplanin,but more than 74.3% of them resistant to rifampicin.The resistance rate of E.faecium to ampicillin,penicillin and levofloxacin were higher than 92.3% and that of E.faecalis were lower than 22.5%.The resistant rate of E.faecium to gentamicin（high level）and nitrofurantoin was also higher than that of E.faecalis.Only the resistant rate to tetracycline was contrary.Conclusion：The resistance rate of E.faecium to most antibiotics is higher than that of E.faecalis.Vancomycin-resistant Enterococcus have been found,which should be paid close attention to.