心元胶囊对高血压病患者血管内皮氧化性损伤干预作用的研究

STUDY ON INTERVENTION OF XINYUAN CAPSULE ON VASCULAR ENDOTHELIAL OXIDATIVE DAMAGE IN PATIENTS WITH HYPERTENSION

目的:观察心元胶囊对高血压病患者血管内皮氧化性损伤的防治作用。方法:将81例病人随机分为治疗组和对照组,分别给予心元胶囊和安慰剂,观察比较两组治疗前后过氧化氢、过氧化脂质、内皮素、一氧化氮、一氧化氮合酶、超氧化物歧化酶及临床症状的变化。结果:治疗组血管内皮功能改善明显优于对照组。结论:心元胶囊可调节ET/NO水平,抗血管内皮过氧化损伤,保护血管内皮功能。

Objective:To observe the preventive and therapeutic effects of xinyuan capsule on vascular endothelial oxidative damage of hypertension patients.Methods:81 cases with hypertension were divided into treated group and control group at random,xinyuan capsule and placebo were given them respectively,the clinical symptoms and signs changes before and after treatment were observed,the hydrogen peroxide,lipid peroxidate(LPO),endothelin(ET),nitric oxide(NO),nitric oxide synthetase(NOS)and superoxide dismutase(SOD)level were determined before and after treatment.Results:The curative effect of treated group was significant better than that of the control,the hydrogen peroxide,lipid peroxidate(LPO)and endothelin(ET)level in the treated group were decreased obviously,the nitric oxide(NO),nitric oxide synthetase(NOS)and superoxide dismutase level were increased significantly.Conclusion:Xinyuan capsule can protect the vascular endothelial function of hypertension patients by adjusting ET/NO level and preventing vascular endothelial oxidative damage.