冠通方对冠状动脉裸金属支架植入术后再狭窄的影响

Effect of Guantong Formula on the Restenosis after Intracoronary Bare Stenting

目的观察冠通方对冠状动脉内裸金属支架植入术后再狭窄的影响。方法120例冠心病冠状动脉裸金属支架植入患者随机分为对照组和治疗组各60例,对照组常规用药,治疗组在此基础上服用冠通方,两组均治疗6个月。冠状动脉定量分析术前、术后即刻和治疗结束后冠状动脉造影图像,比较治疗后两组再狭窄率及支架植入血管段内径情况。结果对照组再狭窄率为23.73%,治疗组为9.84%,两组再狭窄率比较差异有统计学意义(P<0.05)。治疗后治疗组晚期内径丢失小于对照组(P<0.05),支架植入血管段最小内径、管腔内径净获得、管腔面积净获得均大于对照组(P<0.05或P<0.01)。结论冠通方可减少冠状动脉裸金属支架植入术后再狭窄的发生率。

Objective To evaluate the effect of Guantong Formula（Formula for the stenosis of coronary artery）on the restenosis after intracoronary bare stenting.Methods Totally 120 patients after successful intracoronary bare stenting were randomized into control group and treatment group.The control group was treated with routine medicines,based on which the treatment group was administered Guantong Formula.The treatment course was 6 months.Quantitative coronary analysis was made for all patients with the angiograms of pre-intervention,post-intervention and follow-up for comparing the incidence of restenosis and diameter of involved blood vessel of both groups.Results The coronary angiographic examination showed that the restenosis rate of the control group was 23.73% while that of the treatment group was 9.84%,the difference was significant（P0.05）.After treatment,in the late stage,the loss of diameter in the treatment group was smaller than that of the control group（P0.05）,the minimum diameter,the net gain of luminal diameter,and the net gain of luminal area were all larger than those of the control group（P0.05 or P0.01）.Conclusion Guantong Formula is effective in preventing restenosis after intracoronary bare stenting.