肝上皮样血管内皮瘤临床病理观察

Epithelioid hemangioendothelioma of liver:one case report and literature review

目的探讨肝上皮样血管内皮瘤的临床病理特征及诊断要点。方法通过HE切片及免疫组化染色观察1例肝上皮样血管内皮瘤,并结合文献讨论。结果肿瘤由呈树突状和巢状排列的上皮样内皮细胞组成。肿瘤细胞形成胞质内管腔和空泡,内可见红细胞,核偏位,类似印戒样细胞;部分区域肿瘤细胞在血管内形成乳头状、息肉样及出芽状突出物结构。免疫组化示肿瘤细胞CD31和CD34(+)。结论肝上皮样血管内皮瘤是一种低度恶性的血管源性肿瘤,临床少见,易误诊为癌,免疫组化有助于对该病的诊断及鉴别诊断。

Purpose To investigate the clinicopathological features and to explore the major diagnostic points of epithelioid hemangioendothelioma. Methods One case of epithelioid hemangioendothelioma was studied histopathologieally and immunohistochemieally, followed by review of related literature. Results Histologically, the tumor consisted of epithelioid cells, which were dendritical or nests arranged. The cells frequently formed intraeellular lumen and vacuoles, in which red blood cells can be seen. Some cells looked like signet ring cells and some cells formed papillary, porlypoid or budding-like structure in vessels. Immunohistochemical stains showed that tumor ceils were strongly positive for CD31 and CD34. Conclusion Epithelioid hemangioendothelioma of liver is a rare, low grade tumor and it is easily misdiagnosed as carcinoma. Immunohistochemistry plays an important role in its diagnosis and diffrerntial diagnosis.