肝硬化患者胃肠功能障碍机制研究进展

Research progress of the mechanism of gastrointestinal dysfunction in patients with liver cirrhosis

肝硬化患者胃肠功能障碍常加重和加快病情发展,威胁患者生命。主要表现为胃肠道的基本电节律紊乱、胃肠排空时间延迟和胃十二指肠运动改变等。其发生机制尚未明确,可能与门脉高压导致胃肠道长期缺氧、淤血、胃肠道平滑肌神经元功能受损等多种因素有关。笔者就胃肠动力障碍和肠道菌群紊乱及其机制研究进展进行综述。

Gastrointestinal dysfunction in patients with liver cirrhosis often aggravates and accelerates the disease and threatens patients＇ lives. Rhythm disorders, delayed gastric emptyin$ and gut dysmotility are the main clinical presentations. The mechanism remains unclear. It may be correlated with long-term hypoxia gastrointestinal stasis induced by portal hypertension, damage of gastrointestinal smooth muscle neurons and other factors. This review focuses on gastrointestinal motility obstacle and alteration of intestinal flora and the mechanism.