期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Wnt信号通路在运动预防2型糖尿病中的潜在作用 被引量：1

下载PDF
导出
摘要 Wnt信号通路在胚胎发育和肿瘤的发生过程中起着重要作用,近年研究发现该通路的异常与肥胖、胰岛素抵抗（insulin resistance,IR）和2型糖尿病（type 2 dia-betes mellitus,T2DM）的发生也密切相关。有研究表明该信号通路的激活可以抑制机体脂肪细胞的增生,并能调节胰岛β细胞的形态和功能。
作者 刘素娟 牛燕媚 傅力
机构地区 天津体育学院健康与运动科学系 天津医科大学康复与运动医学系
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2010年第3期372-374,共3页 Chinese Journal of Sports Medicine
基金 国家自然科学基金(30871213) 天津市应用基础及前沿技术重点研究计划(09JCZDJC17400)
关键词 WNT信号通路 2型糖尿病 潜在作用 运动预防 胰岛素抵抗 胰岛Β细胞 发生过程 胚胎发育
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献35

  • 1Tommasi S,Pinto R,Pilato B,et al. Molecular pathways and related target therapies in liver carcinoma. Curr Pharm Des, 2007,13(32 ) : 3279-87.
  • 2Lindvall C, Bu W, Williams BO, et al. Wnt signaling, stem cells,and the cellular origin of breast cancer. Stem Cell Rev, 2007,3(2): 157-68.
  • 3Schinner S. Wnt-signaling and the metabolic syndrome. Horm Metab Res,2009,41(2): 159-163.
  • 4Michael Bordonaro. Role of Wnt signaling in the development of type 2 diabetes. Vitam Horm, 2009,80: 563-81.
  • 5Kei Sakamoto, Amolds DE, Ekberg I,et al. Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle. Biochem Biophys Res Commun,2004,319 (2): 419-425.
  • 6Wojtaszewski JF, Nielsen P, Kiens B, et al. Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise. Diabetes,2001,50 (2) : 265-269.
  • 7Aschenbach WG, Ho RC, Sakamoto K, et al. Regulation of Dishevelled and β-catenin in rat skeletal muscle: an alternative exercise-induced GSK-313 signaling pathway. Am J Physiol Endocrinol Metab,2006,291 ( 1 ) :E152-E158.
  • 8Inoki K,Ouyang H, Zhu T,et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell,2006,126(5 ) : 955-68.
  • 9Wodarz A,Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 1998,14:59-88.
  • 10Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions of Writ proteins and their receptors. Cell Signal, 2007,19(4):659-671.

二级参考文献38

  • 1刘敏,母义明.AMPK在运动介导的骨骼肌糖脂代谢中的作用[J].国外医学（内分泌学分册）,2005,25(3):205-207. 被引量：6
  • 2解雪芬,朱毅.AMPK与代谢综合征[J].基础医学与临床,2006,26(1):27-34. 被引量：21
  • 3田爱平,郭赛珊,申竹芳.高脂饲料与胰岛素抵抗动物模型[J].中国药理学通报,2006,22(3):267-269. 被引量：52
  • 4汪茂荣（综述）,李蓉（综述）,任伟（审校）,张素华（审校）.AMPK与2型糖尿病关系研究进展[J].内分泌外科杂志,2007,1(2):132-134. 被引量：4
  • 5Hawley JA and Lessard SJ. Exercise training-induced improvements in insulin action. Acta Physiol, 2008, 192 (1): 127--135.
  • 6Frederick M. Current Protocols in Molecular Biology. Joho Wiley and Sons. Inc, 2007. 29B. 3.7--29B. 3.9.
  • 7Winzell MS, Nogueiras R, Dieguez C, et. al. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun, 2004,321 (1): 154--160.
  • 8Yamauehi T, Kamon J, Waki H, et al. The fat-derived hormone adiponeetin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001, 7 (8) : 941--946.
  • 9Berg AH, Combs TP, Du X, et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med, 2001, 7 (8):947--953.
  • 10Stefan N, Vozarova B, Funahashi T, et al. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes, 2002, 51 (6): 1884-- 1888.

共引文献40

同被引文献17

  • 1Groenewoud MJ,Dekker JM,Fritsche A,et Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretionduring hyperglycaemic clamps[J].Diabetologia,2008,51(9):1659-1663.
  • 2Okada Y,Kubo M,Ohmiya H,et al.Common variants atCDKALl and KLF9 are associated with body mass indexin east Asian populations[J].Nat Genet,2012,44(3):302-306.
  • 3Vazquez-roque MI,Camilleri M,Vella A,et al.Associationof TCF7L2 allelic variations with gastric function,satiationand GLP-I levels[J].CTS,2011,4(3):183-187.
  • 4Huertas-vazquez A,Plaisier C,Weissglas-volkov D,et al.TCF7L2 is associated with high serum triacylgilcerol anddifferentially expressed in adipose tissue in families withfamiliar combined hyperlipidaemia[J].Diabetologia,2008,51:62-69.
  • 5Ruchat S M,Elks C E,Loos R J,et al.Evidence of interac-tion between type 2 diabetes susceptibility genes and di-etary fat intake for adiposity and glucose homeostasis-re-lated phenotypes[J].J Nutrigenet Nutrigenomics,2009,2:225-234.
  • 6Li X,Song F,Jiang H,et alA genetic variation in the fatmass-and obesity-associated gene is associated with obesi-ty and newly diagnosed type 2 diabetes in a Chinese popu-lation[J].Diabetes Metab Res Rev,2010,26(2):128-132.
  • 7Hotta K,Kitamoto T,Kitamoto A,et al.Assocoation ofvariation in the FTO,SCG3 and MTMR9 genes with meta-bolic syndrome in a Japanese population[J].J Hum Gen-et,2011,56(9):647-651.
  • 8Mohamed M H,Gad G I,Ibrahim HY,et al.Cord blood re-sistin and adiponectin in term newborns of diabetic moth-ers[J].Arch Med Sci,2010,6(4):558-566.
  • 9Schinner S.Wnt-signalling and the metabolic syndrome[J].HormMetab Res,2009,1(2):159-163.
  • 10Michael Bordonaro.Role of Wnt signaling in the develop-ment of type 2 diabetes[J].Vitam Horm,2009,80:563-581.

引证文献1

二级引证文献4

中国运动医学杂志
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部