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NALP1:一种新的参与炎症和凋亡的胞内蛋白 被引量：6

NALP1:a novel intracellular protein involved in inflammation and apoptosis
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摘要 NALP1(NACHT leucine-rich-repeat protein 1)属于NLRs(NOD-like receptors)家族中一员,主要参与炎症体(inflammasome)的组装活化以及凋亡体(apoptosome)的诱导形成,从而在炎症反应和细胞凋亡的调节机制中发挥着重要的生物学作用。此外,鉴于NALP1在神经变性性疾病、血液疾病、自身炎症性疾病以及感染性疾病中差异性表达以及致病性作用,将为NALP1相关疾病提供新的诊断和治疗依据。 NACHT leucine-rich-repeat protein 1（NALP1） is a newly identified member of the NOD-like receptors（NLRs） family of cytoplasmic proteins which had been implicated in the activation of inflammasome and apoptosome,playing an important role in the mechanisms of inflammatory and apoptotic regulation.Furthermore,based on the contribution to a group of diseases,including neurodegenerative diseases,hematopathy,autoinflammatory diseases and infectious diseases,NALP1 might provide an invaluable tool to define diagnosis and therapy.
作者 隋江东 李华 吴玉章
机构地区 第三军医大学全军免疫学研究所
出处 《免疫学杂志》 CAS CSCD 北大核心 2010年第5期457-460,共4页 Immunological Journal
关键词 NLR NALP1 CASPASE 炎症 凋亡 NLR NALP1 Caspase Inflammation Apoptosis
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens[J]. Trends Immunol,2005,26(8):447-454.
  • 2闫鸿斌,高闪电,贾万忠,才学鹏.细胞内模式识别受体研究进展[J].免疫学杂志,2008,24(3):359-362. 被引量：12
  • 3Tschopp J, Martinon F, BURNS K. NALPs: a novel protein family involved in inflammation [J]. Nat Rev Mol Cell Biol, 2003,4(2):95-104.
  • 4Hlaing T, Guo RF, Dilley KA, et al. Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins[J]. J Biol Chem,2001,276(12):9230-9238.
  • 5Chu ZL, Pio F, Xie Z, et al. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-depmendent easpase activation and apoptosis [J]. J Biol Chem,2001,276 (12): 9239-9245.
  • 6Martinon F, Hofmann K, Tschopp J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation [J]. Curr Biol,2001,11 (4): R118-120.
  • 7Petrilli V, Papin S, Tschopp J. The inflammasome [J]. Curr Biol,2005,15(15):R581.
  • 8Liu F, Lo CF, Ning X, et al Expression of NALPI in cerebellar granule neurons stimulates apoptosis [J]. Cell Signal,2004,16(9):1013-1021.
  • 9Sanz C, Calasanz MJ, Andreu E, et aL NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells[J]. Biochem J,2004,38d: 281-286.
  • 10Hiller S, Kohl A, Fiorito F, et al. NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain [J]. Structure,2003,11 (10): 1199-1205.

二级参考文献30

  • 1宋明娟,俞瑾,吴根诚.白介素-1受体拮抗剂的抗炎性疼痛作用[J].国外医学（生理病理科学与临床分册）,2004,24(4):386-388. 被引量：8
  • 2韦叶生,蓝艳,蒙兰青,张梁,邓元央.白细胞介素1β和受体拮抗剂的基因型及血清水平与脑卒中的关系[J].免疫学杂志,2005,21(1):54-58. 被引量：3
  • 3Janeway C A, Medzhitov R. Innate immune recognition [ J]. Annu Rev Immunol, 2002, 20: 197- 216.
  • 4Akira S, Takeda K. Toll-like receptor signalling [J]. Nature Rev Immunol, 2004, 4(7): 499-511.
  • 5Martinon F, Tschopp J. NLRs join in TLRs as innate sensors of pathogens [J]. Trens Immunol,2005, 26(8): 447-454.
  • 6Ogura Y, lnohara N, Benlto A, et al. Nod2, a Nodl/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB [ J ]. J Siol Chem, 2001, 276 (7) : 4 812 - 4 818.
  • 7Vival J, Chaput C, Boneca IG, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island [ J]. Nat Immunol, 2004, 5 (11): 1 166-1 174.
  • 8Chamaillard M, Hashimoto M, Horie Y, et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid [ J ]. Nat Immunol, 2003, 4(7) : 702 - 707.
  • 9Opitz B, Puschel A, Schmeck B, et al. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae [ J ]. J Bio Chem, 2004, 279(35) : 36 426 - 36 432.
  • 10Ferwerda G, Girardin SE, Kullberg BJ, et al. NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacteirum tuberculosis [J]. PLoS Pathog, 2005, 1(3) : 279 - 255.

共引文献11

同被引文献95

  • 1程翔,廖玉华.炎症与动脉粥样硬化[J].中华心血管病杂志,2004,32(5):475-477. 被引量：87
  • 2王颖,耿伟,谭洁,沈志祥.熊果酸对结肠癌细胞作用机制的初步研究[J].武汉大学学报（医学版）,2005,26(4):487-490. 被引量：6
  • 3徐连根,潭洁,耿伟,沈志祥.凋亡相关基因caspase-9,bax及bcl-2在大肠癌中的表达及其意义[J].临床消化病杂志,2006,18(1):25-27. 被引量：7
  • 4胡琼,李维山,郑洪.卵巢黏液性肿瘤caspase-3、caspase-9和Smac的表达及其意义[J].临床与实验病理学杂志,2007,23(2):156-158. 被引量：9
  • 5DeYoung KL, Ray ME, Su Y, et al. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma[J]. Oncogene, 1997, 15(4): 453-457.
  • 6Choubey D, Walter S, Geng Y, et al. Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma)gene from the 200-gene family [J]. FEBS Lett, 2000, 474(1): 38-42.
  • 7Mori Y, Yin J, Rashid A, et al. lnstabilotypinff.eomprehensive identification of frameshift mutations caused by coding region mierosatellite instability[J]. Cancer Res, 2001, 61(16): 6046-6049.
  • 8Woerner SM, Kloor M, Sehwitalle Y, et al. The putative tumor suppressor aim2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers[J]. Genes Chrom Cancer, 2007, 46(12): 1080-1089.
  • 9Patsos G, Germann A, Gebert J, et al. Restoration of absent in melanoma 2(AIM2) induces G2/M cell cycle arrest and promotes invasion ofcolorectal cancer cells[J]. IntJ Cancer, 2010, 126(8): 1838-1849.
  • 10Chen IF, Ou-yang F, Hung JY, et al. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model[J]. Mol Cancer Ther, 2006, 5 (1): 1-7.

引证文献6

二级引证文献9

免疫学杂志
2010年 第5期

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