外用钙调磷酸酶抑制剂治疗面部脂溢性皮炎

Topical calcineurin inhibitors in the treatment of facial seborrheic dermatitis

脂溢性皮炎是一种常见的炎症性皮肤病,以红斑、鳞屑、不同程度瘙痒为特征,好发于皮脂腺分泌旺盛部位,给患者的生活、工作带来影响.由于其具有慢性、复发性的特点,更需要一种安全有效的、可以长期使用的治疗手段.过去,脂溢性皮炎的治疗主要为抗真菌药、角质剥脱剂和糖皮质激素.近年,外用免疫调节剂成为慢性炎症性皮肤病的新型治疗方法.多项脂溢性皮炎的临床研究表明,钙调磷酸酶抑制剂,如他克莫司、吡美莫司治疗面部脂溢性皮炎安全有效.

Seborrheic dermatitis is a common inflammatory skin condition characterized by erythema,scaling and pruritus with a predilection for areas rich in sebaceous glands. It affects patients＇ quality of life to an extent. Since it is a chronic and recurrent disease, there is a strong need for safe alternatives for its longterm management. In the past, antifungals, topical corticosteroids and keratolytics were the mainstay of its therapy. Now topical calcineurin inhibitors provide a safe alternative treatment for it. It has been demonstrated that such calcineurin inhibitors as pimecrolimus and tacrolimus are effective and safe in the treatment of facialseborrheic dermatitis.