丙型肝炎病毒蛋白在转基因模型中的作用机制研究进展

Advances in understanding the role of HCV proteins in the pathogenesis of HCV-induced liver diseases in animal models

丙型肝炎病毒(hepatitis Cvirus,HCV)与肝炎、肝硬化和肝癌的发生密切相关.由于HCV通常只在人和高级灵长类动物中形成自然感染,因此极少有研究建立HCV长期感染的实验室模型,HCV感染的病理生理学变化及其与宿主相互作用的相关研究也因此受到限制.近年来,转基因技术为研究人类疾病的分子机制提供了方法,在此基础上开展的转基因细胞系,嵌合体和转基因动物模型在感染性疾病研究中的价值已得到证实.本文综述了近年来HCV转基因模型中HCV蛋白相关的可能致病机制.

Hepatitis C virus （HCV） is closely associated with the occurrence of hepatitis,cirrhosis and liver cancer.As HCV naturally infects only humans and higher primates,few animal models of HCV infection have been established.As a result,limited knowledge on the pathophysiology of and host immune responses to HCV infection is obtained.Gene transfer approaches have been used to establish relevant animal models to investigate the molecular basis of HCV-induced liver diseases.This paper focuses on providing an overview of the recent advances in understanding the role of HCV proteins in the pathogenesis of HCVinduced liver diseases in animal models.