摘要
目的:观察洛铂(LBP)联合5-氟尿嘧啶(5-Fu)与甲酰四氢叶酸(CF)治疗晚期胃癌的临床疗效及不良反应.方法:回顾性分析我科2004-03/2008-09收治的30例具有完整临床资料的晚期胃癌患者接受LBP联合5-Fu与CF方案治疗的情况.LBP30mg/m2静滴,第1天;5-FU300mg/m2静滴,第1-5天;CF100mg/m2静滴,第1-5天,3wk为1周期,至少接受2个周期化疗后按照WHO标准评估疗效及不良作用.结果:30例患者共进行124个周期化疗,中位3(2-6)个周期,其中完全缓解(CR)0例,部分缓解(PR)12例,稳定(SD)5例,进展(PD)13例,客观有效率(ORR)为40%(12/30),临床肿瘤控制率(TCR)为56.7%(17/30).不良作用主要是骨髓抑制与胃肠道反应,而肝功能异常及神经系统毒性等较轻,无明显肾毒性和心脏毒性、未发生因化疗产生严重不良作用而终止治疗者和化疗相关性死亡病例.结论:LBP联合5-FU与CF治疗晚期胃癌疗效确切,不良反应可以耐受,值得临床深入研究、推广.
AIM：To evaluate the efficacy and safety of lobaplatin （LBP） plus 5-fluorouracil （5-FU） and leucovorin （CF） in the treatment of advanced gastric cancer.METHODS：The clinical data for 30 patients with advanced gastric cancer treated with LBP plus 5-FU and CF from March 2004 to September 2008 were retrospectively reviewed.All patients received at least two cycles of chemotherapy,each lasting 21 days and consisting of LBP 30 mg/m^2 IV d 1,5-FU 300 mg/m^ 2 IV d 1-5,and CF 100 mg/m^ 2 IV d 1-5.RESULTS：Thirty patients received 2 to 6 cycles of chemotherapy,with a median of three cycles.All patients were evaluable for efficacy and toxicity.No patients obtained a complete response.Partial response was achieved in 12 patients,stable disease in 5 patients,and progressive disease in 13 patients.The objective response rate was 40% （12/30）.The tumor control rate was 56.7% （17/30）.Therapy was generally well tolerated.Major toxicity was myelosuppression and gastrointestinal sensitivity,including anaemia,thrombocytopenia,leukocytopenia,and nausea and vomiting.No chemotherapy-related death occurred.CONCLUSION：LBP plus 5-FU and CF regimen is effective and safe for patients with advanced gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第10期1063-1066,共4页
World Chinese Journal of Digestology
