连豆清脉方对冠心病患者血浆致动脉粥样硬化指数及高敏C反应蛋白的影响

Effect of Liandou Qingmai Recipe on Atherogenic Indices of Plasma and High-sensitivity C-reactive Protein in Patients with Coronary Heart Disease

目的观察连豆清脉方对冠心病患者血浆致动脉粥样硬化指数(AIP)和高敏C反应蛋白(hs-CRP)的干预作用。方法将68例冠心病患者,随机分为连豆清脉方治疗组(简称观察组,35例)和标准治疗组(简称标准组,33例),两组均进行冠心病标准化治疗,其中观察组加用连豆清脉方(由连翘、黄连、野料豆、赤芍、莱菔子等组成,本院制剂室统一配制,每剂煎250 mL,每日两次口服,疗程2周),检测治疗前后甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,计算AIP;并观察hs-CRP、外周血白细胞(PBL)变化。结果治疗前标准组和观察组TG、LDL-C、HDL-C及AIP,hs-CRP、PBL差异均无统计学意义(P>0.05)。与治疗前比较,治疗后标准组AIP、TG均升高,hs-CRP、PBL均下降,但差异无统计学意义(P>0.05),而LDL-C、HDL-C下降,差异有统计学意义(P<0.05);观察组则各项指标均较治疗前下降(P<0.05),其中AIP、TG以及hs-CRP、PBL明显低于标准组(P<0.05)。结论连豆清脉方可以同时降低冠心病患者LDL-C浓度和AIP,增加LDL-C颗粒直径,并进一步降低hs-CRP、PBL,具有抗动脉粥样硬化、抗炎症作用。

Objective To observe the intervention effects of Liandou Qingmai Recipe（LQR） on atherogenic indices of plasma（AIP） and high-sensitivity c-reactive protein（hs-CRP） level in patients with coronary heart disease（CHD）.Methods Sixty-eight CHD patients were randomly assigned to two groups,35 patients in the treatment group and 33 in the control group,all were treated by the regular CHD treatment,but to patients in the treatment group,LQR was given additionally.AIP value was calculated before and after treatment through measuring plasma levels of triglyceride（TG）,high-density and low-density lipoprotein cholesterol（HDL-C and LDL-C）.Besides,the levels of hs-CRP and peripheral blood leucocyte（PBL） were observed as well.Results No significant difference existed between groups in all the detected parameters before treatment（P〈0.05）.After treatment,levels of LDL-C,HDL-C,hs-CRP and PBL lowered significantly in the control group,but the changes of AIP and TG were insignificant（P〈0.05）;while in the treatment group,all the parameters lowered significantly,with the levels of AIP,TG,hs-CRP and PBL significantly lower than those in the control group respectively（P〈0.05）.Conclusion LQR can decrease levels of AIP and hs-CRP in CHD patients,amplify the diameters of LDL-C granule,and further lower hs-CRP and PLB levels,showing anti-atherosclerosis and anti-inflammation effects.