α-氰基丙烯酸正丁酯在选择性肝动脉栓塞中的应用

The Usage of NBCA in Transcatheter Selective Hepatic Arterial Embolization

目的:评价应用α-氰基丙烯酸正丁酯(N-butyl2-cyanoacrylate,NBCA)选择性栓塞肝动脉的安全性和有效性。材料和方法:2008-09～2009-12解放军总医院就诊的20例患者,包括外科术后出血2例、原发性肝癌合并肝动-静脉瘘形成11例、多囊肝7例,男性13例,女性7例;年龄45-65岁,应用NBCA进行选择性肝动脉栓塞。结果:所有选择性栓塞均成功,无严重并发症。2例外科术后出血患者在栓塞结束后出血即停止,分别随访6个月、8个月,均未再发生出血。11例原发性肝癌合并肝动-静脉瘘患者中9例患者瘘口闭合,2例患者瘘口明显缩小。7例多囊肝患者栓塞区囊肿范围均不同程度缩小。结论:应用NBCA进行选择性肝动脉栓塞的近期疗效是安全、可靠的,但其栓塞的远期效果仍有待进一步观察。

Objective To elevate the efficacy and safety of the usage of NBCA in tranacatheter selective hepatic arterial embolization.Materials and Methods From Sep 2008 to Dec 2009,20 patients（13 male and 7 female,age ranged from 45 to 65）including 2 cases of hemorrhage after surgery,11 cases of hepatocellular carcinoma combined of hepatic arterial-portal vein shunt,and 7 cases of polycystic liver disease.NBCA was used to the hepatic arteries embolization.Results Technical success of interventional treatment was achieved in all 20 cases with no severe complications.The bleeding ceased immediately after interventional treatment of the 2 hemorrhage cases and no recurrence bleeding in the follow up of 6 and 8 months.9 fistulas were successfully embolized and 2 fistulas were partially embolizad in 11 cases of hepatocellular carcinoma combined with hepatic arterial-portal vein shunt.The cyst volume was decreased in 7 cases of polycystic liver disease.Conclusion The short-term efficacy of transcatheter selective hepatic arterial embolization with NBCA was safe but need follow-up to verify long-term efficacy.