血浆基质金属蛋白酶-9与血管假性血友病因子浓度在急性脑梗死早期诊断中的意义

Significance of MMP-9 and vWF concentrations in the early diagnosis of acute cerebral infarction

目的研究血浆基质金属蛋白酶-9(MMP-9)、血清血管假性血友病因子(vWF)浓度在急性脑梗死发病早期(<6 h)的变化。方法检测脑功能损害体征持续存在>1 h,年龄<75岁患者的MMP-9、vWF浓度,根据最终诊断区分脑梗死组及非梗死组,比较MMP-9、vWF浓度的变化。结果急性脑梗死早期外周血MMP-9、vWF水平即有升高,如果以MMP-9>160μg/L、vWF>150μg/L为标准对急性脑梗死早期(<6 h)进行诊断,发病4～6 h的敏感性和特异性为92.3%和92.9%。结论以MMP-9>160μg/L、vWF>150μg/L为标准对急性脑梗死发病后4 h诊断有较高的特异性和敏感性,值得临床推广。

Objective To investigate the changes of plasma matrix metalloproteinase-9（MMP-9）,serum von willebrand factor（vWF） concentrations in patients with acute cerebral infraction of early period（〈6 h）.Methods To detect brain function damage signs persistence exceed 1 h,age〈75 years patients MMP-9,vWF concentration,according final diagnosis differentiate cerebral infarction group and non infarction group and compare MMP-9,vWF concentration changes.Results The acute cerebral infarction peripheral MMP-9,vWF level that was higher.If MMP-9〉160 μg/L,vWF〉150 μg/L as the standard of acute cerebral infarction（〈6 h） for diagnosis of disease,4-6 h sensitivity and specificity was of 92.3% and 92.9%.Conclusion It has a high specificity and sensitivity with MMP-9〉 160 μg / L,vWF 〉150 μg / L as the standard 4 h after the onset of acute cerebral infarction diagnosed and worthy to be popularized.