注射用黄芪多糖对鼻咽癌放射治疗患者免疫功能的影响

The astragalus polysaccharide injection on immune function in nasopharyngeal carcinoma patients treated with conventional radiotherapy

目的观察注射用黄芪多糖对鼻咽癌放射治疗患者免疫功能的影响。方法采用随机分组方法将32例鼻咽癌放射治疗患者随机分成治疗组和对照组,每组各16例。对照组进行单纯常规放射治疗,治疗组于常规放射治疗第1天开始,注射用黄芪多糖针250 mg加入5%葡萄糖溶液(GS)中静脉滴注,每日1次,连续用3周,间歇1周,重复应用,直到放疗终止。观察两组患者治疗前后外周血CD4+、CD8+、CD4+/CD8+和NK淋巴细胞的数据变化。结果对照组放疗后CD8+细胞和NK淋巴细胞百分数较放疗前略微增加,其他检测指标较放疗前均有下降,且差异无统计学意义(P>0.05)。而治疗组治疗后除CD8+下降外,CD3+、CD4+、NK淋巴细胞百分数、CD4+/CD8+值明显升高,并明显高于治疗前和对照组的水平(P<0.01)。结论注射用黄芪多糖可明显增强鼻咽癌放射治疗患者的细胞免疫功能。

Objective To observe the astragalus polysaccharide injection on immune function in nasopharyngeal carcinoma patients treated with radiation effects.Methods Take a randomized method to divide 32 cases of nasopharyngeal carcinoma patients into treatment group and control group,16 patients in each group.The control group only take conventional radiotherapy,the treatment group started being injected 250 mg astragalus polysaccharide injection which added into 5% GS once a day as the conventional radiotherapy started,for 3 weeks then intermittent 1-week,repeat application until the termination of radiotherapy.Observed the data changes of the patient＇s peripheral blood CD4^＋,CD8^＋,CD4^＋/CD8^＋ and NK lymphocytes before and after the treatment.Results CD8^＋ cells and NK cell percentage in control group increased slightly after radiotherapy than before radiotherapy,and other test indicators were down compared with before radiotherapy,and the difference was not statistically significant（P〉0.05）.In treatment group after treatment except CD8^＋ decreased,CD3^＋,CD4^＋,NK cell percentages,CD4/CD8^＋ were significantly increased,and significantly higher than before treatment and the level of the control group（P〈0.01）.Conclusion The injection of astragalus polysaccharide can significantly enhance the cell mediated immunity function of the nasopharyngeal carcinoma patients who treated with conventional radiotherapy.