焦炉工血清丙二醛和尿β_2-微球蛋白的变化

Alteration of serum MDA and urinary β_2-microglobulin in workers exposed to coke oven emissions

目的探讨焦炉作业工人血清中丙二醛(MDA)及尿β2-微球蛋白(β2-MG)的水平及意义。方法选择106名焦炉作业工人作为接触组,72名无任何职业有害物质接触史的体检者作为对照组。采集空腹静脉血和尿样,用试剂盒检测血清MDA和尿β2-MG水平。结果与对照组比较,接触组焦炉工血清MDA水平明显增高;经尿肌酐校正后的尿β2-MG水平高于对照组,差异有统计学意义(P<0.05)。在接触组中,炉顶工血MDA和尿β2-MG水平均高于炉侧工和炉底工,差异有统计学意义(P<0.05)。178名调查者血MDA和尿β2-MG呈正相关。结论焦炉逸散物可导致焦炉工人生物膜氧化损伤和早期的肾损害,可以把血清MDA和尿β2-MG一起作为焦炉工人职业损害的检测指标。

Objective To evaluate the changes and significance of serum malondialdehyde （MDA） and urine β2-microglobulin（β2-MG） in workers exposed to coke oven emissions （COE）.Methods Serum MDA and urine β2-MG were measured respectively in 106 cases of coke oven workers （exposure group） and 72 healthy workers without any occupational carcinogen exposure （control group） with TAB colorimetry and ELISA method.Results The levels of serum MDA and urine β2-MG in coke oven workers were significantly higher than those in the controls （P0.05）.In the exposure group,the levels of serum MDA and urine β2-MG in oven top workers were higher than those in oven side and bottom workers （P0.05）.Among respondents,the levels of serum MDA were positively correlated to urine β2-MG.Conclusion COE can result in obvious biomembrane and kidney damage in the exposed workers.Indexes such as MDA and urine β2-MG may be used to detect occupational adverse effect on coke oven workers.