氨丙基修饰MCM-41的制备及载药释药性能研究

Study the performance of drug loadding and release on aminopropyl modified MCM-41-(CH_2)_3NH_2/hydrochlorothlazide

用微波辅助水热法和共缩聚法分别制备了介孔分子筛MCM-41和氨丙基修饰的介孔分子筛MCM-41-(CH2)3NH2,将利尿药物氢氯噻嗪组装到两种材料中,用XRD、FT-IR、低温N2吸附、TG对分子筛及药物组装体进行表征,测定了组装体的载药量以及在人工胃液中的释放行为。结果显示MCM-41经氨丙基修饰后仍保持六方孔道结构,虽然孔径略有减小,但活性点位增加,仍有较大的载药量(38.23%),MCM-41和MCM-41-(CH2)3NH2载药体系均能实现缓释。修饰后释药速率进一步减慢,且随着氨丙基接枝量的增加递减,表明可通过氨丙基修饰量来调节释放速率。

In this paper,mesoporous molecular sieve MCM-41 and MCM-41-（CH2）3NH2 were respectively synthesized using microwavefunctionalized by using the γ-aminopropyl triethoxyl silicane and the aminopropyl modified MCM-41-（CH2）3NH2 was succesfully synthesized. The diuretic hydrochlorothlazide was induced into the before and after modified mesoporous molecular sieve. The before and after modified MCM-41,assemblies were charactered by XRD,FT-IR,low-temperature Nitrogen absorption,TG. Drug loading of assemblies and the release in simulating body fluid were carried. The results showed that the pore size slightly decreased after aminopropyl modification. the hexagonal structure of MCM-41 was still maintain. Drug loading was larger （38.25%）.The release rate decrease after modification with the increase amount of aminopropyl.