主动外排机制介导鲍曼不动杆菌多重耐药研究进展

Efflux Pump Mediated Multidrug Resistance in Acinetobacter baumannii

鲍曼不动杆菌是医院感染和机会感染的主要致病菌之一,并且其耐药性高,常发生泛耐药或多重耐药。主动外排机制在细菌多重耐药发生中起着重要的作用。与鲍曼不动杆菌多重耐药有关的外排蛋白主要有AdeABC、AdeIJK、Tet(A)、Tet(B)和AbeM外排泵。本文结合当前主动外排机制研究进展,对与鲍曼不动杆菌多重耐药有关的主动外排蛋白的分类、组成、基因表达调控以及耐药情况进行综述。通过对鲍曼不动杆菌主动外排机制的深入研究,对新型抗菌药物的开发和治疗方法的改进有着极大的推动作用。

Acinetobacter baumannii is a major pathogen of nosocomial and opportunistic infections. And the clinical isolates are frequently resistant to many commonly used antimicrobial agents. Patients in intensive care units have a high incidence of colonization with multidrug resistance（MDR） or pandrug resistance（PDR） strains. Active effiux system exemplify a unique phenomenon in drug resistance： a single mechanism causing resistance against several different classes of antibiotics. Several efflux systems have been reported in A. baumannii： including AdeABC, AdeIJK, Tet（A）, Tet（B） and AbeM. This review is focused on the classification, structure, genetic organization, regulation of gene expression, and the threat of multi-drug resistance of these efflux pumps in A. baumannii. Further studies of these efflux pumps is very important for us to searching a new medicine or a new therapeutic solutions for clearing the multidrug resistant A.baumannii infections.