IGF-Ⅱ、HIF-1α在胃癌组织中的表达及意义
摘要
胰岛素样生长因子-Ⅱ(IGF-Ⅱ)和缺氧诱导因子-1α(HIF-1α)在肿瘤的发生发展中期起重要的作用。本研究应用免疫组化方法,检测IGF-Ⅱ、HIF-1α蛋白在胃癌组织中的表达情况,并结合临床分期及病理进行分析,以探讨两者在胃癌组织中的表达意义、关系。
参考文献3
-
1Role of IGF-Ⅱ.Endocrionology,1996,137(5):1764-1769.
-
2Zhong H,De Marzo AM,Lauguner E,et al.Overexpression of hypoxia-inducible factor lalpha in common human cancers and their metastases.Cancer Res,1999,59(220):5830-5835.
-
3任学群,索智敏,傅侃达,景红,吴江.结直肠腺瘤及癌组织中缺氧诱导因子-1α的表达[J].郑州大学学报（医学版）,2004,39(4):648-650. 被引量：5
二级参考文献11
-
1Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol , 2000,88(4):1 474
-
2Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Ann Rev Cell Dev Biol, 1999, 15:551
-
3Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev, 2000,14(16):1 983
-
4Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res, 1999,59(22):5 830
-
5Birner P, Gatterbauer B, Oberhuber G, et al. Expression of hypoxia-inducible factor-1α in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer, 2001,92(1): 165
-
6Birner P, Schindl M, Obermair A, et al. Overexpression of hypoxia-inducible Factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res, 2000, 60(17):4 693
-
7Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res, 2001, 61(7):2 911
-
8Chen J, Zhao S, Nakada K,et al.Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol, 2003,162(4):1 283
-
9Zhong H,Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1 α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeut
-
10Watanabe T,Muto T.Cotorectal carcinogenesis besed on molecula biology of early Colorectal Canter,with speical reference to nonpoiypoid(Superficial) lesions. World J Surg,2000,24(9):1 091
共引文献4
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1张更谦,周斌,杜冰,杨志惠,张蓓蕾,朱银华,张林.鼠窒息后缺氧诱导因子1-α在心、肺中的表达[J].法医学杂志,2006,22(6):407-410. 被引量：2
-
2李尚坤,傅仲学,李明洋.结直肠肿瘤中缺氧诱导因子-1α表达的Meta分析[J].重庆医科大学学报,2009,34(7):934-937. 被引量：1
-
3王红磊,王洪涛,赵鹏.IGF-II、HIF-1α和CD105在胃癌中的表达及其意义[J].临床医学工程,2011,18(5):668-670. 被引量：8
-
4杨春发,姚家麟,刘红宝.HIF-1α,VEGF-C在胃腺癌中表达及与淋巴结转移的关系[J].航空航天医学杂志,2011,22(11):1299-1304.
-
1王红磊,王洪涛,赵鹏.IGF-II、HIF-1α和CD105在胃癌中的表达及其意义[J].临床医学工程,2011,18(5):668-670. 被引量：8
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2齐法莲,朱彤宇,杜秀敏,徐军,杨道理.卵巢癌和子宫内膜癌患者血清TGF-α和IGF-Ⅱ的水平[J].免疫学杂志,2003,19(1):81-81.
-
3郑艳莉,刘曼华,鲁晓燕,陶潜,杨其昌,朱燕.IGF-Ⅱ和HGF的表达与卵巢癌微血管密度的关系[J].南通大学学报（医学版）,2009,29(6):427-429. 被引量：2
-
4匡蕾.子宫颈癌患者手术治疗前后血清IGF-Ⅱ、SCC和CYFRA21-1检测的临床意义[J].放射免疫学杂志,2010,23(3):259-260. 被引量：1
-
5南云广,丁海波,刘大林,顾丹.胃癌患者手术前后血清IGF-Ⅱ、TGF-α和TNF-α检测的临床评价[J].放射免疫学杂志,2012,25(5):497-499. 被引量：4
-
6周敏杰,李少民,夏焘,刘瑛.食管癌患者术前术后血清Hcy、TSGF、IGF-Ⅱ的改变及临床意义[J].海南医学,2017,28(8):1278-1280. 被引量：6
-
7朱德义,刘家喜.ACI患者血清IGF-Ⅱ、IL-8和TNF-α水平的变化及临床意义[J].放射免疫学杂志,2012,25(5):516-517. 被引量：3
