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结肠癌原发灶及肝转移灶中PTEN蛋白的表达研究 被引量：1

STUDY ON EXPRESSION OF PTEN PROTEIN IN PRIMARY COLON CANCER AND LIVER METASTASIS
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摘要 目的检测结肠癌原发灶及淋巴结、肝转移灶中PTEN蛋白的表达情况及其作用。方法应用免疫组化方法和WesternBlot方法对38例结肠癌原发灶和淋巴结、肝转移灶中PTEN蛋白的表达情况进行检测。结果PTEN蛋白质原发灶中高表达,在淋巴结转移灶中表达降低,肝转移灶中不表达或表达极低。结论PTEN蛋白表达降低有助于结肠癌的转移,PTEN可望成为结肠癌预后指标和分子治疗的靶标。 Objective To study the expression and function of PTEN protein in primary colon cancer and lymph node and liver metastasis.Methods We detected PTEN protein expression in 38 cases with immunohistochemistry and western blot. Results We found high PTEN protein expression in primary cancer and low or no expression in lymph node and liver metastasis.Conclusion Low PTEN protein expression probably contributes to metastasis of colon cancer, so PTEN might be a prognostic marker and molecular treatment target of colon cancer.
作者 张永红 于冬冬 何乐亚 魏欣 陶德定 胡俊波 龚建平
机构地区 华中科技大学同济医学院附属同济医院胃肠外科肿瘤研究所
出处 《中国组织化学与细胞化学杂志》 CAS CSCD 2010年第1期85-87,共3页 Chinese Journal of Histochemistry and Cytochemistry
基金 国家"973"子课题(2004CB518705 2009CB521802) 国家自然科学基金(30872472 30800569) 新世纪人才支持计划(NCET-04-0699)
关键词 PTEN蛋白 原发灶 肝转移 PTEN protein Primary focus Metastasis
分类号 R735.7 [医药卫生—肿瘤]
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参考文献6

  • 1Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyroaine phosphatase gene mutated in human brain,breast,and prostate cancer.Science,1997,275(5308):1943-1947.
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同被引文献28

  • 1江志坚,王小平.PTEN及nm23-H1蛋白表达在非小细胞肺癌转移中的意义[J].中国肺癌杂志,2008,11(6):793-797. 被引量：4
  • 2Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer l Clin, 2011, 61(2): 69-90.
  • 3Shaukat A, Mongin SJ, Geisser MS, et al. Long-Term mortality after screening for colorectal cancer. N Engl J Med, 2013, 369(12): 1106- 1114.
  • 4Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin, 2014, 64(2): 104-117.
  • 5Stambolic V, Suzuki A, De La Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 1998, 95(1): 29-39.
  • 6Ma JC, Sawai H, Matsuo Y, et al. Interleukin-lalpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines. J Surg Res, 2008, 148(2): 197-204.
  • 7Ma JC, Sawai H, Matsuo Y, et al. IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res, 2010, 160(1): 90-101.
  • 8Hollander MC, Blumenthal GM, Dennis PA. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer, 2011, 11(4): 289-301.
  • 9Ma JC, Sawai H, Matsuo Y, et al. IGF-1 and PTEN regulate the proliferation and invasiveness of colon cancer cells through opposite effects on PI3K/Akt signalling. Arch Med Sci, 2009, 2: 195- 206.
  • 10Ma JC, Sawai H, Ochi N, et al. PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem, 2009, 331(1-2): 161-171.

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中国组织化学与细胞化学杂志
2010年 第1期

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