桔梗水提醇沉上清部分对链脲菌素致糖尿病大鼠糖耐量影响的研究

Influence of the ethanol fraction from Platycodon grandiflorum on glucose tolerance of streptozotocin-induced diabetic rat

目的:研究桔梗水提醇沉上清部分对链脲菌素(STZ)致糖尿病大鼠糖耐量的影响。方法:采用STZ腹腔注射配合高能饲料制备糖尿病大鼠模型,分别以含2、8g/kg的桔梗水提醇沉上清稀释液、拜唐苹和纯水进行大鼠28d灌胃实验,观察大鼠的糖耐量、血清胰岛素水平(INS)、胰岛素敏感指数(ISI)及胰腺的组织形态学变化。结果:相对于模型组,药物高剂量组大鼠糖耐量水平有显著改善,INS及ISI水平均有所升高,胰腺损伤程度明显减轻。结论:桔梗水提醇沉上清部分能通过提高糖尿病大鼠的胰岛素敏感性,部分修复其胰腺损伤,从而有效改善其糖耐量水平。

Objective：To study the effect on the glucose tolerance of the diabetic kunming rat of the ethanol fraction from Platycodon grandiflorum A.DC.Methods：Diabetic kunming rat models were induced by i.p.injection of streptozotocin（STZ）assisted with high energy diet,and were divided into different groups,which were given 28d of 2,8g/kg ethanol fraction from Platycodon Grandiflorum A.DC,Acarbose or water respectively.Then the glucose tolerance,serum insulin levels（INS）and insulin sensitivity index（ISI）were tested and the pathology damage of the pancreatic were examined.Result：High doses of the ethanol fraction from Platycodon grandiflorum A.DC improved glucose tolerance,INS,ISI more evidently,and alleviated the pancreas tissue injury.Conclusion：The improvement of the the ethanol fraction from Platycodon grandiflorum A.DC on glucose tolerance related to the improvement of the ISI and the partial repair of the diabetic rats＇ pancreas tissue.