非多囊卵巢综合征患者的体重指数对体外受精-胚胎移植结局的影响

Effects of Body Mass Index on the Outcome of Patients Without PCOS Receiving in Vitro Fertilization and Embryo Transfer Treatment

目的:探讨非多囊卵巢综合征患者体重指数(BMI)对体外受精-胚胎移植(IVF-EF)结局的影响。方法:回顾性分析168例非多囊卵巢综合征患者的IVF-ET周期的结局。按BMI分为偏瘦组(BMI<18.5 kg/m2)、正常体重组(18.5 kg/m2≤BMI<24 kg/m2)、超重及肥胖组(BMI≥24 kg/m2)3组,比较3组患者的促性腺激素(Gn)用药天数和剂量,HCG注射日E2水平、获卵数、受精率、优胚率、种植率、临床妊娠率、流产率。结果:超重及肥胖组(BMI≥24 kg/m2)的Gn用量与其余两组相比有统计学差异(P<0.05),其余指标3组间无统计学差异(P>0.05)。结论:排除多囊卵巢综合征患者后,超重及肥胖患者与正常体重及偏瘦患者相比,在进行IVF-ET促排卵过程中需要更大的Gn用量,而超重及肥胖对IVF-ET的结局无显著影响。

Objective： To investigate the effect of body mass index（BMI） of patients without polycystic ovary syndrome（PCOS） on the outcome of in vitro fertilization and embryo transfer（IVF-ET） treatment.Methods： The pregnancy outcomes of 168 patients underwent IVF-ET treatment were analyzed according to different BMI ranges： BMI18.5 kg/m^2,18.5 kg/m^2≤BMI〈24 kg/m^2,and BMI≥24 kg/m^2.Results： The ampules of gonadotropin used were more in BMI≥24 kg/m^2 group as compared with the other two groups（P〈0.05）,while no significant differences were found among the three groups in age,infertility years,basic levels of FSH,fertilization rate,and estradiol（E2） on the day of injecting human chorionic gonadotropin（hCG）,implantation rate of embryo,clinic pregnancy rate and miscarriage rate.Conclusion： Overweight and obese patients,independent to PCOS,require a higher gonadotropin dose to achieve follicular maturation than normal weight patients.Overweight and obesity does not affect negative results of IVF-ET.