生长分化因子15与心血管疾病

Growth Differentiation Factor-15 and Cardiovascular Disease

生长分化因子15属于生长分化因子家族,是转化生长因子β超家族的成员之一。既往发现,生长分化因子15在风湿性关节炎、炎症、肿瘤、贫血等情况下表达增加,近年发现生长分化因子15的增高与心力衰竭、急性冠状动脉综合征、原发性肺动脉高压等疾病密切相关,在心衰及其他心血管疾病中独立反映疾病预后,可能是心血管系统中一个新的生物标志物。

Growth differentiation factor-15（GDF-15） which belongs to the GDF family is a member of TGF-β super family.The previous researches indicated that GDF-15 increased its expression in the condition of rheumatoid arthritis,inflammation,tumor,anemia and so on.During recent years,it was found that increased level of GDF-15 was associated with heart failure（HF）,acute coronary syndrome（ACS）,idiopathic pulmonary arterial hypertension（IPAH） and other cardiovascular diseases.GDF-15 which provides independent prognostic information in HF and other cardiovascular diseases might be a new promising biomarker.