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体质量及BMI对肝脏3.0T单体素MR波谱抑水效果的影响

Effect of body mass and BMI on proton hepatic MRS water suppression at 3.0T MR
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摘要 目的探讨并比较受检者体质量及体质量指数(BMI)对在体肝脏3.0T质子MRS预扫描抑水效果的影响。方法44名志愿者,使用GESigna Excite HD3.0T超导磁共振扫描仪,8通道腹部相控阵线圈,单体素PRESS序列采集。参数为TR/TE1500ms/30ms,NSA64次,VOI2cm×2cm×2cm。采用SAGE进行后处理分析得到代谢物峰高及峰下面积。结果体质量较小组较体质量较大组的平均身高小[分别为(161.2±8.5)cm、(167.7±6.2)cm],平均BMI较小[分别为(20.8±2.3)kg/m2,(25.6±2.6)kg/m2],抑水效果更好(两组min—max分别为90—96、65—94;中位数为94、93)。Lip2峰高(两组min—max分别为1.41×104—5.76×105、3.45×104—1.75×106;中位数分别为9.00×104、2.58×105)及峰下面积(两组min—max分别为4.27×104—2.00×107、1.24×105—5.00×107;中位数分别为2.64×105、1.19×106)较小。标准化脂质含量(min—max分别为0—0.11、0—0.96;中位数分别为0.01、0.04)更小。BMI较低组较BMI较高组平均体质量较小[分别为(55.2±8.2)kg、(71.2±7.8)kg],平均年龄较小[分别为(33.2±11.9)岁、(45.6±9.4)岁],抑水效果更好(两组min—max分别为90—96、65—95;中位数分别为94、93)。Lip2峰高(两组min—max分别为1.41×104—5.76×105、3.45×104—1.75×106;中位数分别为7.37×104、2.11×105)及峰下面积(两组min—max分别为4.27×104—2.00×107、1.24×105—5.00×107;中位数分别为2.64×105、1.19×106)较小。标准化脂质含量(min—max分别为0—0.08、0.01—0.96;中位数分别为0.01、0.04)更小。体质量与抑水率、BMI与抑水率等级相关系数分别为-0.478、-0.494。结论体质量及BMI增加伴随肝脏脂质沉积增加,影响波谱预扫描抑水效果,均为中等负相关,肥胖受检者更难达到良好的波谱预扫描结果从而更难获得高分辨的可析性波谱,BMI较体质量对预测略为敏感。 Objective To explore the effect of body mass and body mass index (BMI) on proton hepatic MRS water suppression at 3.0T. Methods The prospective study of hepatic proton MRS was performed with GE Signa Excite HD 3.0T system and eight-channel torso phased-array coils using PRESS sequence in 44 healthy subjects. Liver spectra were collected with TR of 1500 ms,TE of 30 ms,VOI of 2 cm×2 cm×2 cm and NSA of 64 times. Areas and heights for metabolites resonances were caulculated. Results Group with small mass has lower height ([161.2±8.5] cm vs [167.7±6.2])cm,lower BMI ([20.8±2.3] kg/m2 vs [25.6±2.6]kg/m2),better water suppression effect (min—max:90—96 vs 65—94; median:94 vs 93),smaller height (min—max:1.41×104—5.76 ×105 vs 3.45×104—1.75×106; median:9.00×104 vs 2.58×105) and integrated area (min—max:4.27×104—2.00×107 vs 1.24×105—5.00×107; median:2.64×105 vs 1.19×106)of Lip2 than larger weight group. Standardized lipid content (min—max:0—0.11 vs 0—0.96; median:0.01 vs 0.04) was less. Group with lower BMI had lower weight ([55.2±8.2]kg vs [71.2±7.8]kg),smaller age ([33.2±11.9]years vs [45.6±9.4]years),better water suppression effect(min—max:90—96 vs 65—95; median:94 vs 93) smaller of height (min—max:1.41×104—5.76×105 vs 3.45×104—1.75×106; median:7.37×104 vs 2.11×105) and integrated area (min—max:[4.27×104—2.00×107] vs [1.24×105 —5.00×107]; median:2.64×105 vs 1.19×106) of Lip2 than larger weight group. Standardized lipid content (min—max:0—0.08 vs 0.01—0.96; median:0.01 vs 0.04) was less. There was significant correlation among water suppression,weight (r=-0.478,P=0.001) and BMI (r=-0.494,P=0.001). Conclusion Lipid accumulation in the liver may be the result of increased fat portion of the body depending on mass and BMI,and hinder to achieve effective water suppression.
出处 《中国医学影像技术》 CSCD 北大核心 2010年第4期705-708,共4页 Chinese Journal of Medical Imaging Technology
基金 国家自然科学基金(30800269) 广东省科技计划资助项目(2005B10401040 2007B031515008) 广东省自然科学基金资助项目(5001199)
关键词 磁共振波谱 肝脏 单体素 Magnetic resonance spectroscopy Liver Single volume spectroscopy
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参考文献10

  • 1吴坚,叶慧义,孙非,张静,梁燕,马林,蔡幼铨,杨立.肝细胞癌3.0TMR氢质子波谱的初步研究[J].中国医学影像技术,2006,22(12):1856-1859. 被引量:17
  • 2白亮彩,郭顺林,周怀琪,雷军强,窦郁,张毅.1H MRS在定量分析脂肪肝中的初步研究[J].中国医学影像技术,2006,22(4):529-531. 被引量:27
  • 3Fischbach F,Schirmer T,Thormann M,et al.Quantitative proton magnetic resonance spectroscopy of the normal liver and malignant hepatic lesions at 3.0 Tesla.Eur Radiol,2008,18(11):2549-2558.
  • 4Kuo YT,Li CW,Chen CY,et al.In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T MR scanner.J Magn Reson Imaging,2004,19(5):598-604.
  • 5Katz-Brull R,Rofsky NM,Lenkinski RE.Breathhold abdominal and thoracic proton MR spectroscopy at 3T.Magn Reson Med,2003,50(3):461-467.
  • 6Muller C,Hubner F,Bisdas S,et al.In vivo proton MR spectroscopy of normal liver parenchyma:technique and results.Rofo,2006,178(11):1128-1136.
  • 7Garbow JR,Lin X,Sakata N,et al.In vivo MRS measurement of liver lipid levels in mice.J Lipid Res,2004,45(7):1364-1371.
  • 8Starcuk Z Jr,Starcuk Z,Mlynarik V,et al.Low-power water suppression by hyperbolic secant pulses with controlled offsets and delays (WASHCODE).J Magn Reson,2001,152(1):168-178.
  • 9Haddadin IS,McIntosh A,Meisamy S,et al.Metabolite quantification and high-field MRS in breast cancer.NMR Biomed,2009,22(1):65-76.
  • 10Jansen JF,Backes WH,Nicolay K,et al.^1H MR spectroscopy of the brain:absolute quantification of metabolites.Radiology,2006,240(2):318-332.

二级参考文献16

  • 1范明霞,田建明,陆建平,金爱国,曾浩.活体^1H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究[J].中国医学影像技术,2004,20(10):1503-1505. 被引量:23
  • 2叶慧义,赵瑞峰,李永才,梁燕,于国,高元桂.MRI诊断含脂质肝脏肿瘤的价值[J].中国医学影像学杂志,2004,12(5):340-343. 被引量:9
  • 3Gholam PM,Kotler DP,Flancbaum LJ.Liver pathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery[J].Obes Surg,2002,12(1):49-51.
  • 4Bugianesi E,Leone N,Vanni E,et al.Expanding the natural history of nonalcoholic steatohepatitis:from cryptogenic cirrhosis to hepatocellular carcinoma[J].Gastroenterology,2002,123(1):134-140.
  • 5Sheth SG,Gordon FD,Chopra S.Nonalcoholic steatohepatitis[J].Ann Intern Med,1997,126(1):137-145.
  • 6Lefkowitch S.Liver Biopsy Interpretation[M].5th ed.Philadelphia:WB Saunders Company,1994.
  • 7Suzuki K,Hayashi N,Sasaki Y,et al.Dependence of ultrasonic attenuation of liver on pathologic fat and fibrosis:examination with experimental fatty liver and liver fibrosis models[J].Ultrasound Med Biol,1992,18(8):657-666.
  • 8Choji T.Evaluation of fatty liver changes and fatty degeneration in liver tumors by 1H-MRS[J].Nippon Igaku Hoshasen Gakkai Zasshi,1995,53(2):1408-1414.
  • 9Kuo YT,Li CW,Chen CY,et al.In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T MR scanner[J].J Magn Reson Imaging,2004,19(5):598-604.
  • 10Dixon RM.NMR studies of phospholipid metabolism in hepatic lymphoma[J].NMR Biomed,1998,11(5):370-379.

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