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KPC碳青霉烯酶及检测的研究进展 被引量：9

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摘要 KPC是2001年发现的一类具有碳青霉烯水解活性的A类丝氨酸β-内酰胺酶,至今,至少有5种变异酶组成(KPC-1～KPC-5),其编码基因位于可转移质粒。可有效水解几乎所有β-内酰胺类抗生素,包括青霉素类、头孢菌素类、单酰胺类和碳青霉烯类,其活性可被克拉维酸和他唑巴坦所抑制。此外,KPC编码基因常与其他类抗生素(如氟喹诺酮类和氨基糖苷类)耐药基因联合,这将最终限制有效治疗药物的选择。若按CTX-M和质粒介导AmpC的传播速度推算,可以想象,KPC的广泛传播必将给医学界带来严峻挑战。
作者 李金钟 刘利平
机构地区 河北省新乐市医院
出处 《国际检验医学杂志》 CAS 2010年第4期357-359,共3页 International Journal of Laboratory Medicine
关键词 Β内酰胺酶类 克雷伯菌 肺炎 抗药性 细菌 碳青霉烯酶
分类号 R446.5 [医药卫生—诊断学]
  • 相关文献

参考文献25

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  • 2Rasheed JK,Biddle JW,Anderson KF,et al.Detection of the Klebsiella pneumoniae carbapenemase Type 2 carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K.oxytoca carrying a common plasmid[J].J Clin Microbiol,2008,46(6):2066-2069.
  • 3Tibbetts R,Frye JG,Marschall J,et al.Detection of KPC-2 in a clinical isolate of proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC β-lactamase in P.mirabilis[J].J Clin Microbiol,2008,46(9):3080-3083.
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  • 8Woodford N,Zhang JC,Warner M,et al.Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom[J].J Antimicrob Chemothe,2008,62(6):1261-1264.
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二级参考文献11

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共引文献5

同被引文献64

引证文献9

二级引证文献30

国际检验医学杂志
2010年 第4期

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