氨氯地平与依那普利在高血压合并冠心病患者中的联合应用

Combined application of amlodipine and enalapril in CAD patients with hypertension

目的:评价固定药物组合的疗效和耐受性:在舒张压≤85mmHg情况下,氨氯地平+依那普利组与氨氯地平组在高血压合并冠心病患者的应用比较。方法:双盲,随机研究,入选患者为舒张压在≥90和<110mmHg之间同时具有冠状动脉疾病。将患者随即分成两组,A组采取联合用药治疗,B组单用氨氯地平治疗,疗程12周。结果:在80名入选患者中,两组患者治疗前后的舒张压(DAP)和收缩压(SAP)下降有显著差异,(p<0.01);但是,组间比较没有统计学差异。在12周中,A组患者比B组患者下肢水肿发病率低。结论:联合用药与单用氨氯地平一样,对于高血压合并冠心病患者和心绞痛(SAH)I、II级的患者有效。另外,联合应用依那普利和氨氯地平可阻滞肾素血管紧张素系统的作用,减少下肢水肿的发生。

Objective：To evaluate the efficacy and tolerability of the fixed combination：amlodipine ＋ enalapril,when compared to amlodipine in the diastolic arterial pressure（DAP）（≤85 mmHg）,in patients with CAD and systemic arterial hypertension（SAH）.Methods：Double-blind and randomized study。With two groups of patients with DAP ≥90 and 110 mmHg and CAD.Patients were randomly distributed for the use of the combination（A） or amlodipine（B） and were followed up to 12 weeks.Results：Of the 80 selected patients,the decreases in DAP and systolic arterial pressure（SAP） were significant（p 0.01）,but with no difference between the groups in mmHg。Group A presented a lower incidence of lower-limb edema.Conclusion：The fixed combination of enalapril and amlodipine,as well as isolated amlodipine,was effective in the patients with CAD and SAH stages I and II,adding blockage of the renin-angiotensin system to reduce the lower-limb edema.