阿尔茨海默病及轻度认知功能障碍的生物学标志物
被引量:3
摘要
随着年龄的增加,MCI进展为AD的几率愈来愈大,而早期AD与其它痴呆有时又难以鉴别,所以寻找对MCI、AD早期诊断及鉴别诊断特异性高的生物学标志物成为临床研究的重点。本文就MCI、AD患者脑脊液及血液方面的生物学标志物进行综述。
出处
《国际精神病学杂志》
2010年第2期96-99,共4页
Journal Of International Psychiatry
参考文献15
-
1Riemenschneider M, Lautenschlager N, Wagenpfeil S, et al. Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment. Arch Neurol. 2002; 59 (11) : 1729-1734.
-
2Buerger K, Teipel SJ, Zinkowski R, et al. CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology, 2002; 59 (4) : 627-629.
-
3Buerger K, Teipel SJ, Zinkowski R, et al. Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment. Neurosci Lett. 2005 ; 391 ( 1-2 ) : 48-50.
-
4Hampel H, Buerger K, Zinkowski R, et al. Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. Arch Gen Psychiatry, 2004 ; 61 ( 1 ) : 95-102.
-
5Boban M, GrbicK, Mladinov M, et al. Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia. Coil Antropol. 2008 ; 32 Suppl 1 : 31-36.
-
6Hu YY, He SS, Wang X, et al. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients: an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. Am J Pathol. 2002 ; 160 (4) : 1269-1278.
-
7Tarkowski E, Andreasen N, Tarkowski A, et al. Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry, 2003; 74 (9) : 1200-1205.
-
8Ji JP, Meng R, Sun YX, et al. Cerebrospinal fluid tau, Abetal-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neurosci Lett. 2005 ; 383 (1-2) : 12-16.
-
9Rosenberg RN, Baskin F, Fosmire JA. Altered amyloid protein processing in platelets of patients with Alzheimer disease. Arch Neurol. 1997; 54 (2) : 139-144.
-
10宇辉,张志珺,施咏梅,柏峰,袁勇贵,钱云,谢春明.遗忘型轻度认知功能损害患者血清脑源性神经营养因子及血浆组织型纤溶酶原激活剂水平变化及其临床意义[J].临床神经病学杂志,2008,21(3):198-200. 被引量:2
二级参考文献11
-
1薛寿儒,杨小旺.血小板β-淀粉样肽前体蛋白免疫强度及异构体比率对Alzheimer病的诊断价值[J].临床神经病学杂志,2007,20(3):176-178. 被引量:5
-
2Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome [ J]. Arch Neurol, 1999, 56: 303.
-
3Peng SY, Wuu J, Mufson E J, et al. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease [ J ]. J Neurochem, 2005, 93 : 1412.
-
4Melchor JP, Pawlak R, Strickland S. The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration [J]. J Neurosci, 2003, 23:8867.
-
5Aggarwal NT, Wilson RS, Beck TL, et al. Mild cognitive impairment in different functional domains and incident Alzheimer's disease [J].J Neurol Neurosurg Psychiatry, 2005, 76: 1479.
-
6Pang PT, Teng HK, Zaitsev E,et al. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity [ J ]. Science, 2004, 306: 487.
-
7Selkoe D.I. Alzheimer's disease is a synaptic failure [J]. Science, 2002, 298 : 789.
-
8Counts SE, Nadeem M, Lad SP. Differential expression of synaptie proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment [ J]. J Neuropathol Exp Neurol, 2006, 65 : 592.
-
9Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets [ J ]. Neurosci Let, 2002, 328: 261.
-
10Laske C, Stransky E, Leyhe T, et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls [J]. J Psychiatric Res, 2007, 41: 387.
同被引文献45
-
1孟超,张新卿,王姮,孙厚亮,刘宏军,汤哲,陈彪.画钟测验检测认知功能损害[J].中国神经精神疾病杂志,2004,30(6):452-454. 被引量:20
-
2史伟雄,郭起浩,洪震,陆骏超,吕传真.轻度认知功能损害患者的听觉词语记忆特点[J].中华老年医学杂志,2006,25(2):93-96. 被引量:20
-
3李龙宣,赵斌,许志恩,邢孔鸯,唐荣华.痴呆患者血清和脑脊液中炎前和抗炎细胞因子的变化[J].第四军医大学学报,2007,28(5):453-455. 被引量:14
-
4Ritchie K,Touchon J.Mild cognitive impairment:conceptual basis and current nosological status[J].Lancet,2000;355(9199):225-8.
-
5Winblad B,Palmer K,Kivipelto M,et al.Mild cognitive impairment:be-yond controversies,towards a consensus[J].Intern Med,2004;256(3):240-6.
-
6Collie A,Maruff P.The neuropsychology of preclinical Alzheimer's dis-ease and mild cognitive impairment[J].Neurosci Biobehav Rev,2000;24(3):365-74.
-
7Petersen RC,Smith GE,Waring SC,et al.Mild cognitive impairment:clinical characterization and outcome[J].Arch Neurol,1999;56(3):303-8.
-
8Petersen RC,Doody R,Kurz A,et al.Current concepts in mild cognitive impairment[J].Arch Neurol,2001;58(12):1985-92.
-
9Luis CA,Loewenstein DA,Acevedo A,et al.Mild Tmpairment:directions for future research[J].Neurology,2003;61(4):438-44.
-
10Barker A,Jones R,Jennison C.A prevalence study of age-associated memory impairment[J].Br J Psychiatry,1995;167(5):642-8.
引证文献3
-
1吴越,程灶火.轻度认知障碍的研究进展[J].中国老年学杂志,2013,33(9):2215-2217. 被引量:20
-
2林巧,孟秀君,李明,任玉峰,方蔷,刘俊,张圆圆.认知障碍程度对阿尔茨海默病患者脑脊液各类炎性细胞因子表达影响[J].西北国防医学杂志,2013,34(6):533-536. 被引量:5
-
3佟久芬,于秀萍,张新春,王金朋,陶秀娟.基于社区医院的老年轻度认知障碍的整体治疗[J].国际精神病学杂志,2016,43(4):651-654.
二级引证文献25
-
1杨清.老年性痴呆症状 病因及防治措施[J].基层医学论坛,2013,17(35):4756-4757. 被引量:1
-
2马漪洁,韩雪萍.氟比洛芬酯用于老年患者术后镇痛的效果及对认知功能的影响[J].河南外科学杂志,2014,20(6):54-56. 被引量:4
-
3赵建刚,邬天凤,韩峰梅,马菲,黄国伟.天津市社区老年人轻度认知功能障碍人口学特征分析[J].中华疾病控制杂志,2015,19(4):330-333. 被引量:25
-
4刘莹.微信组群管理对居家轻度认知障碍患者的影响[J].天津护理,2015,23(2):105-106. 被引量:1
-
5胡科,张保朝,贾东佩.健脑补肾丸联合银杏叶片治疗轻度认知功能障碍[J].中国实验方剂学杂志,2015,21(23):160-163. 被引量:5
-
6肖稳,丁萍,杨飞.阿尔茨海默病早期生物标记物及其检测方法的研究进展[J].中国预防医学杂志,2016,17(3):225-228. 被引量:4
-
7陆永利,杨红卫.大麻素在突触可塑性和学习记忆中的作用[J].中国老年学杂志,2016,36(10):2565-2567.
-
8吴春幸,阮时宝,褚克丹.轻度认知功能障碍的中医康复疗法研究[J].中国医学创新,2017,14(3):143-145. 被引量:3
-
9单永琳.芪参还五胶囊促进早期血管性痴呆患者智能缺损程度、脂代谢紊乱恢复临床研究[J].亚太传统医药,2017,13(4):152-154. 被引量:13
-
10蒲玉婷,白雪.炎性因子与轻度认知障碍的相关性研究进展[J].中西医结合心脑血管病杂志,2017,15(4):436-438. 被引量:8
-
1方珉,刘学源.血管性认知功能障碍及其早期识别与干预的研究进展[J].上海医药,2016,37(15):5-11. 被引量:6
-
2苑丽萍,张丽萍.肝豆状核变性CT诊断及鉴别诊断[J].吉林医学,2002,23(5):302-302.
-
3王曼,秦晓霞,孙伟.抑郁症的诊断及鉴别诊断[J].中国乡村医生,2000,15(3):10-11.
-
4王志勇,刘剑刚,李浩.阿尔茨海默病和轻度认知功能障碍相关生物学标志物[J].中华老年医学杂志,2016,35(12):1345-1349. 被引量:7
-
5陈英道(综述,石胜良(审校).阿尔茨海默病源性轻度认知功能损害生物学标志物研究进展[J].中风与神经疾病杂志,2013,30(9):847-850. 被引量:2
-
6刘照,刘卫平,肖波,严新翔,李国良,姜海燕,尹蓉,李蜀渝.动态脑电图在癫诊断及鉴别诊断中的价值[J].临床神经病学杂志,2005,18(2):105-107. 被引量:10
-
7郭荷娜,王妮,王倩,陈瑞利,杨谦.急性脑梗死患者血浆脂蛋白相关磷脂酶A2与病情轻重关系的研究[J].中国卫生检验杂志,2016,26(18):2666-2667. 被引量:5
-
8吴婧琳,孟庆慧,侯文霞.轻度认知障碍的相关生物学标志物[J].中国老年学杂志,2012,32(8):1757-1760. 被引量:2
-
9宋为娟,张伟,任真,杨瑞霞.脂蛋白相关磷脂酶A2在缺血性脑血管病中的临床意义[J].江苏医药,2016,42(20):2237-2239. 被引量:2
-
10陈琳,刘宗惠.磁共振波谱分析在帕金森病诊断及鉴别诊断中的应用[J].立体定向和功能性神经外科杂志,2000,13(1):50-53. 被引量:1