脑脊液乳酸脱氢酶检测在脑膜炎诊断中的临床意义

Clinical Significance of LDH Detection in GSF in the Diagnosis of Meningitis

目的探讨脑脊液乳酸脱氢酶(LDH)检测在鉴别细菌性脑膜炎和病毒性脑膜炎的临床应用价值。方法采用速率法检测48例细菌性脑膜炎、45例病毒性脑膜炎以及对照组40例脑脊液LDH和血清LDH的浓度。结果细菌性脑膜炎患者LDH浓度明显高于病毒性脑膜炎患者以及正常对照组(P<0.05);而病毒性脑膜炎患者脑脊液LDH浓度与对照组相比差异无统计学意义(P>0.05)。细菌性脑膜炎血清LDH与病毒性脑膜炎比较差异无统计学意义(P>0.05)。结论脑脊液LDH检测可作为细菌性脑膜炎和病毒性脑膜炎的鉴别诊断,对于临床药物的选择具有重要的指导意义。

Objective To investigate the clinical value of LDH detection in GSF in the identification of bacterial meningitis and viral meningitis. Methods LDH levels in serum and CSF of acterial meningitis（48cases）, viral meningitis（45cases） and control group （40cases） were measured by using enzyme rate method. Results LDH levels of the bacterial meningitis group were significantly higher than viral meningitis group and control greup（P〈0.05）;but there was no significant difference among viral meningitis group and control group（P〉0.05）. There were no significant differences in serum LDH level among bacterial meningitis and viral meningitis（P〉0.05）. Conclusion The CSF-LDH level can used as an distinguish-diagnosis between bacterial meningitis and viral meningitis,it has important guiding significance for the selection of antihypertensive drugs.