P63参与子宫颈病变的研究进展

The reseach development of P63 effection on cervical lesions

P53基因作为明确的抑癌基因,已被广泛而深入地研究,且一直被作为一个单独的基因而不是作为某个基因家族的一员来看待。直至其同源基因P63的发现才使人们更进一步认识到P53基因是属于一个很大的家族。其不局限于肿瘤的发生、发展,更涉及个体的生长与发育。近年研究提出,P63基因将作为宫颈鳞癌及具有向鳞状上皮分化倾向的储备细胞的标志物。因而P63基因在宫颈肿瘤发生、发展过程中都起着重要作用。进一步研究P63基因的结构及表达特点、P63基因在宫颈癌前病变发生发展中所发挥的作用、P63与HPV在宫颈病变中的关系,将有助于探讨在宫颈癌早期诊断中的意义,这已是医学多学科共同研究的热点。

Tumor suppressor gene P53 is widely researched and alaways considered as a single gene not untill the discovery of gene P63.According to further studies,researchers find that Gene P63 and P53 belongs to a huge gene family,they expressed not only in tumor＇s occurrence and development but also in individual＇s growth and development.Recently.Some research adviced on making P63 as a marker of Squamous Cervical Carcinoma and reserve cell which has a conversion tendency of squamous epithelial cells,it shows the important effection of gene P63 in Cervical Tumour.Further research about gene P63 structure and expression features,effection on uterine cervix,correlation with HPV in Cervical Lesions will help us to confirm its significance of Cervical Cancer Early Detection,And that has already been a hotspot in many medical studies