瘀浊清颗粒对高血压大鼠的降压作用及其机制

Impact and Mechanism of Yuzhuoqing Granule on Hypertensive Rats

目的:观察以化瘀浊益肝肾法为治疗原则组方的瘀浊清颗粒对肾型高血压大鼠的降压作用的影响及其机制。方法:雄性SD大鼠采用经典高血压造模方法造模。选择造模成功的大鼠随机分成3组,即对照组,瘀浊清颗粒高剂量组(高剂量组);瘀浊清颗粒低剂量组(低剂量组)。连续给药28天,前后测血压4次。休息4天后,3组大鼠继续给药。其中对照组(A组)和低剂量组(C组)均加用卡托普利50mg/kg,高剂量组(B组)用药不变;再连续给药100天,前后测血压4次。治疗结束后麻醉所有大鼠,经颈静脉取血作血液黏稠度、红细胞聚集率和红细胞变形性检测。结果:给药第28天后,低剂量组和高剂量组大鼠血压与同组造模后比较,差异均具有显著性(P<0.05,P<0.01);瘀浊清颗粒高剂量组(B组)与低剂量组联合卡托普利(C组)及与单用卡托普利组(A组)3组用药前后自身比较均有显著性差异(P<0.05,P<0.01)。结论:瘀浊清颗粒对高血压大鼠有显著降压作用。随着治疗时间的延长,瘀浊清颗粒加用卡托普利的临床疗效好于单用中药或西药。

Objective： To observe impact of Yuzhuoqing Granule, which is formulated according to the stasis resolving and liver - kidney benefiting principle, on hypertensive rats and the mechanism. Methods：To establish the hypertension model by routine methods on male SD rats, which were randomly grouped to receive distilled water （group A）, or the granule at high dosage （group B）/ low （group C） dosage for consecutive 28 days. Take blood pressure for 4 times. After 4 day interruption, resume the same medication with one modifi- cation ： group A and C took Captopril 50mg/kg in addition. Take blood pressure for 4 times. Measure blood viscosity, erythrocyte aggre- gation and RCD. Results：After 28 day, the parameters of group C and B showed significant differences when compared with those before treatment, respectively （P 〈0.05 ,P 〈0.01 ） ; Group B was even better than group C and group B （P 〈0.05 ,P 〈0. O1 ）. Conclusion： Yuzhuoqing Granule has significant anti - hypertension effect on rat models. As shown by prolonged treatment courses, Yuzhuoqing Granule plus Captopril is more effective than each one of them.