宫颈阴道分泌液中IL-8、铜、锌含量与胎膜早破关系的研究

In the cervix of the uterus vagina secretion IL--8, the copper, the zinc content and the fetal membrane break the price record the department early the research

目的：对胎膜早破（PROM）孕妇宫颈阴道分泌液中基质金属白介素-8（IL-8）、微量元素（铜、锌）的含量与PROM的关系进行探讨。方法：选择足月初产胎膜早破孕妇40例（PROM组）和正常足月初产孕妇未破膜者40例（对照组），分别用双抗体夹心ELISA法和溶出电极法测定阴道分泌液中IL-8和铜、锌的含量。结果：PROM组阴道分泌液中IL-8水平平均为657．20±83．33μg／ml，明显高于对照组421．54±22．35pg／ml，差异有显著性（P〈0．01）；PROM阴道分泌液中铜、锌的含量分别为2．18±1．57μg／L，0．45±0．17μg／L，均明显低于对照组3．67±2．07μg／L，0．72±0．36μg／L，差异有显著性（P〈0．01）。结论：PROM组孕妇阴道分泌液中IL-8含量明显升高，而铜、锌含量明显降低，对胎膜早破的早期诊断有一定帮助。

Objective：To fetal membrane early broken （PROM） pregnant woman cervix of the uterus vagina secretion in matrix metal Bai Jiesu - 8（IL-8）, trace element （copper, zinc） the content and the PROM relations carry on the discussion. Method： Chooses the full--term first birth fetal membrane early broken pregnant woman 40 examples （the PROM group） and the normal full -- term first birth pregnant woman not broken membrane 40 examples （control group）, uses the double immune body to contain fill- ing separately the ELISA law and dissolves in the electrode law determination vagina secretion IL--8 and copper, the zinc content. Results：In the PROM group vagina secretion the IL--8 level is 657. 20±83.33μg/ml equally, is higher than control group 421. 54± 22. 35μg/ml obviously, the difference has the significance （P《0.01）. In the PROM vagina secretion copper, the zinc content re- spectively be 2. 18±1.57 μg/L, 0. 45±0.17 μg/L, obviously is lower than the control group 3. 67±2.07 μg/L, 0. 72±0.36 μg/ L, the difference has the significance （P〈0.01）. Conclusions： In the PROM group pregnant woman vagina secretion the IL--8 content elevates obviously, but the copper, the zinc content reduce obviously, has certain help early to the fetal membrane broken early diagnosis.