脑梗死患者颈动脉硬化与纤维蛋白原、C反应蛋白及脂蛋白(a)的相关性研究

Study on the relationship between fibrinogen,lipoprotein a and C-reactive protein and carotid artery sclerosis in patients with cerebral infarction

目的了解纤维蛋白原(Fib)、C反应蛋白(CRP)及脂蛋白(a)(LPa)与脑梗死患者颈动脉硬化的相关性。方法选择2007年1月至2009年1月期间于我院住院就诊的脑梗死患者92例为研究对象。所有患者行颈动脉超声检查及血清Fib、CRP及LPa检查。结果①颈动脉硬化检出率为76.09%;②颈动脉硬化组各指标均高于非颈动脉硬化组(P<0.05);③将检出颈动脉硬化的患者按其斑块性质进行分组,可分为软斑块组、硬斑块组、混合性斑块组,软斑块组和混合性斑块组CRP高于硬斑块组(P<0.05);采用半定量法将患者按斑块严重程度分组,结果发现,随着病变程度加重,患者血清Fib、LPa、CRP浓度有逐渐增高的趋势,三指标在各组间的差异具有统计学意义(P<0.05)。结论 Fib,CRP及脂蛋白(a)在脑梗死颈动脉硬化的诊断及病情判断上具有重要价值。

Objective To investigate the relationship between fibrinogen,lipoprotein a（LPa） and C-reactive protein（CRP） and carotid artery sclerosis in patients with cerebral infarction.Methods Ninety-two cerebral infarction patients treated in our hospital from January 2007 to January 2009 were selected as the study subjects.All of them were examined with carotid ultrasonography,and serum levels of fibrinogen,CRP and LPa were tested.Results ①Rate of carotid artery sclerosis was 76.09%.② The parameters examined above were higher in patients with carotid artery sclerosis than those without carotid arteries sclerosis.③CRP level in patients with soft plaque and mixed plaque was higher than that in patients with hard plaque（P0.05）.With the aggravation of plaque lesion,serum levels of fibrinogen,CRP,and LPa were gradually increased.Conclusion Fibrinogen,CRP,and LPa play important role in the diagnosis and judgement of illness state of carotid artery sclerosis in patients with cerebral infarction.