瘦素和转化生长因子β_1对非酒精性脂肪性肝炎患者肝纤维化的促进作用研究

The advanced effects of leptin and transforming growth factor-beta 1 on liver fibrosis patients with nonalcoholic steatohepatitis

目的针对非酒精性脂肪性肝炎(NASH)患者体内转化生长因子β1(TGF-β1)和瘦素与肝纤维化之间的相关性进行研究,从而阐述两者对肝纤维化的促进作用。方法检测NASH患者血清瘦素水平以及TGF-β1水平,同时检测NASH患者的血清肝纤维化指标透明质酸(HA)、板层素(LN)、Ⅲ型前胶原肽(PCⅢ)等,其结果与单纯性脂肪肝患者及健康对照者进行组间比较,最后对血清瘦素、TGF-β1与肝纤维化指标进行相关性分析。结果 NASH患者血清瘦素水平以及TGF-β1水平明显高于对照组,差异有显著性,并且NASH患者血清瘦素水平、TGF-β1水平以及肝纤维化指标之间呈正相关。结论瘦素和TGF-β1是NASH进展为肝纤维化过程中的重要因子,但其分子机制需进一步深入研究。

Objective The main aim of this study was to examine the relationship between the leptin/ transforming growth factor-beta 1（TGF-beta1） and liver fibrosis in nonalcoholic steatohepatitis（NASH）,and to discuss the advanced effect of leptin/TGF-beta 1 on liver fibrosis.Methods The study included 217 subjects,88 with NASH,81 with simple fatty liver and 50 healthy adults.Leptin and TGF-beta 1 serum levels were determined by RIA.Serum indexes of hepatic fibrosis（HA,LN,PCⅢ） were also examined.The results were compared among the groups and the relationship between the serum levels of leptin and TGF-beta 1 and hepatic fibrosis indexes were analysed.Results There were significant differences between patients with NASH and control group when leptin and TGF-beta1 serum levels were compared.A positive correlation was observed between serum levels of leptin and TGF-beta 1 and serum indexes of hepatic fibrosis.Conclusion The results of the study demonstrates increased serum levels of leptin and TGF-beta 1 in patients with NASH,and they may play an important role in hepatic fibrosis.