WHO分型标准在急性红白血病诊断中的临床应用

WHO classification in clinical diagnosis of acute erythroleukemia

目的探讨WHO分型标准在急性红白血病(AML-M6)诊断中的临床应用价值。方法回顾分析51例WHO分型标准确诊的AML-M6,按法美英(FAB)分型标准重新进行评价,并对其临床特征、外周血、骨髓细胞形态学、细胞化学染色、免疫表型、细胞遗传学及预后情况进行分析研究。结果 51例AML-M6患者粒、红、巨三系均有不同程度病态造血,过碘酸雪夫反应(PAS)对其幼红细胞有特异性。结论形态学特征对AML-M6诊断仍然具有不可替代的地位。

Objective To investigate the clinical application of the WHO criteria for classification of acute erythroleukemia. Methods A retrospective analysis was conducted on 51 cases of WHO criteria for diagnosis of acute erythroleukemia （AML-M6）, according to French-American-British（FAB） classification criteria for re-evaluation, and clinical features, peripheral blood, bone marrow cell morphology, cytochemical staining, immunophenotyping, cytogenetics and analysis of prognosis of the situation. Results Fifty-one patients with AML M6 had dysplasia in varying degrees in granulocyte, erythrocyte and megakaryocyte series. Periodic acid-Shiff reaction（PAS） staining in polychromatic erythroblast and ortho-chromatic erythroblast had specificity in diagnosis of AML-M6. Conclusion Morphological characteristics has an irreplaceable position in the diagnosis of AML-M6.