人乳头状瘤病毒感染与子宫颈病变的关系探讨

Cervical Lesions and Human Papillomavirus Infection:Their Relationship Between

目的探讨不同程度的子宫颈病变患者的人乳头状瘤病毒(HPV)感染情况和HPV-DNA基因亚型分布。方法选取在医院妇科取得宫颈脱落细胞及组织标本的患者550例,用核酸分子快速杂交技术进行HPV-DNA分型检测。结果 550例患者中,有270例(49.1%)HPV检测呈阳性,以16、52、58亚型最为常见,其中HPV16亚型84例(15.3%);270例阳性患者中,正常组91例(30.1%),宫颈上皮内瘤病变(CIN)Ⅰ组57例(55.9%),CINⅡ组48例(72.7%),CINⅢ组18例(90%),宫颈癌组56(93.3%)。结论随着子宫颈病变级别及组织病理学级别的升高,高危型HPV感染的阳性率呈上升趋势.在妇科常规体检中应重视HPV特别是HPV16型的感染监测。

OBJECTIVE To explore the human papillomavirus（HPV） infection in patients with cervical lesions and the distribution of HPV genotype. METHODS A total of 550 cervical samples, including cervical cells and tissues, were collected from women attendingcervical screening in our Southwest Hospital. The cervical scrape specimens were tested using nucleic acid hybridization. RESULTS Of 550 cases, 270 （49. 1%） patients were positive for HPV-DNA. The genotypes 16, 52 and 58 were the most common types, from them 84 cases （15.3%） were with genotype 16. The distributions among normal group, cervical infraepithelial neoplasia （CIN） Ⅰ group, CIN Ⅱ group, CINⅢ group and cervical cancer group were 91 （30. 1%）, 57 （55. 9%）, 48 （72. 7%）, 18 （90%）and 56 （93.3%）, respectively. CONCLUSIONS The positive rate of high risk HPV increases with the severity of cervical lesions. It＇s necessary to monitoring HPV infection, especially HPV 16, in the women health checkup.