1036例静脉吸毒者肝功能及乙肝、丙肝、梅毒、艾滋病感染血清标志物调查分析

Analysis of liver function,HBV,HCV,Syphilis and HIV infection serum marker in 1036 intravenous drug abusers

目的:了解厦门地区静脉吸毒者传染病的感染状况及相关因素,为更有效地预防和控制吸毒人群传染病的感染与传播提供依据。方法:同时收集静脉吸毒者血清1036份和正常人群血清标本874份,进行肝功能、乙肝表面抗原、丙肝抗体、梅毒抗体、艾滋病抗体检测,作对比分析。结果:1036例静脉吸毒者血清标本中,肝功能异常率30.5%;乙肝表面抗原阳性率17.86%;丙肝抗体阳性率55.3%;梅毒抗体阳性率4.5%;艾滋病抗体0.68%;对照实验:874例正常人群,肝功能异常率5.1%,乙肝表面抗原阳性率10.18%,丙肝抗体阳性率2.7%,梅毒抗体阳性率0.8%,艾滋病抗体阳性率为零。两组结果对照的差异性,具有统计学意义。结论:静脉吸毒者肝功能、乙肝、丙肝、梅毒、艾滋病血清学标志物感染率明显高于正常人群,是传染病感染与传播的高危人群。吸毒者的吸毒模式和行为模式是各项传染病感染与传播的主要因素。

Objective： To understand the situation and correlated factor of liver function and epidemic infected that HBV,HCV,syphilis and HIV on 1036 intravenous drug abusers （IVDAS） in Xiamen area. Meth- ods： The collected 1036 example of Application of biochemistry test that liver function and application of ELISA that HbsAg/anti-HCV/antHIVI＋2/TP（RPR positive）from IVDAS, 874 serum example make contrast test from normal crowd. Results： Among 1036 IVDAS,316 （30.5%） were liver function unusual, 185 （17.86%） of HbsAg positive, 573（55.3%） of anti-HCV positive, 47（4.5%） of RPR positive, 7（0.68%） an- ti-HIVl＋2 positive, Contrast experiment showed that 874 serum specimens from normal crowd 45 （5.1%） were liver function unusual, 89（10.18%） of HbsAg positive, 24（2.75%） anti-HCV positive, 13（1.49%） of RPR/TP positive, The anti-HIVl＋2 all negative. There are significant difference between two samples. Conclusion： The IVDAS are easy to be infected by HBV.HCV.syphilis and HIV. Drug use and sex behavior of IVDAS are important factor.