摘要
目的 探讨Ⅱ期结直肠术后复发转移的危险因素.方法 回顾性分析2000年1月至2003年12月我院收治的192例Ⅱ期结直肠癌患者的临床资料,并分析复发转移相关因素.结果 本组患者行根治术后出现复发转移68例,其中肝转移19例,肺转移15例,多脏器转移9例,骨转移5例,腹腔转移5例,脑转移3例,肾转移1例,吻合口复发11例.术前癌胚抗原（CEA）水平、肿瘤分化程度、肿瘤浸润深度、淋巴结清扫个数、有无脉管瘤栓是术后复发转移的主要影响因素（χ~2 值分别为8.566、7.602、6.505、11.892、6.995,P均〈0.05）.logistic 回归分析表明术前CEA水平、肿瘤分化程度及淋巴结清扫个数为Ⅱ期结直肠癌根治术后复发转移的独立危险因素.结论 Ⅱ期结直肠癌术后复发转移最常见部位为肝脏,提高淋巴结清扫个数有助于降低复发转移风险.
Objective To investigate the risk factors of metastasis and recurrence for stage Ⅱcolorectal carcinoma.Methods From January,2000 to December,2003,clinical records of 192 stage Ⅱ colorectal carcinoma patients who had underwent curative resection were retrospectively analyzed.Results 68 patients experienced relapse,including 19 hepatic metastasis,15 pulmonary metastasis,5 bone metastasis,3 brain metastasis,1 kidney meta stasis and 11 stomal recurrence.Preoperative CEA level,histological differentiation,T stage,lymph node harvest and vessel invasion were the main factors correlated with metastasis/recurrence（χ~2 values were 8.566,7.602,6.505, 11.892 and 6.995,P〈O.05）.Logistic regression analysis showed that preoperative CEA level,histological differentiation,and lymph node harvested were independent risk factors.Conclusions Liver is the most common metastatic site after curative resection.Improved lymph node harvest could reduce metastasis or recurrence risk.
出处
《中国综合临床》
2010年第4期341-343,共3页
Clinical Medicine of China
关键词
结直肠癌
复发
转移
危险因素
Colorectal neoplasm
Recurrence
Metastasis
Risk factor
