摘要
目的 探讨宫颈癌组织中胰岛素样生长因子-2（IGF-2）的表达及其与临床病理特征的关系.方法 采用免疫组织化学链霉亲和素-生物素过氧化物酶法检测15例正常宫颈（NCE组）、30例宫颈上皮内瘤变（CIN 组）和50例宫颈癌（SCC 组）中IGF-2的表达.结果 NCE、CIN及SCC组IGF-2阳性表达率分别为0.00%（0/15）、43.33%（13/30）和74.00%（37/50）,从NCE、CIN到SCC组,IGF-2 阳性表达率显著升高（P均〈0.05）.IGF-2 的表达率在盆腔淋巴结转移、组织学分级、间质浸润程度中差异有统计学意义（χ^2分别为8.698,5.162,4.278,P均〈0.05）,且与癌组织对宫颈间质的浸润程度、淋巴结转移呈正相关（r值分别为0.361、0.723,P均〈0.01）.在年龄、国际妇产科联盟（FIGO）临床分期中差异无统计学意义（χ^2值分别为0.435,0.631,P均〉0.05）.结论 IGF-2的高表达与宫颈癌的发生、发展及侵袭转移有关,可能是有价值的肿瘤生物学行为标记物.
Objective To investigate the relationship between the expression of insulin like growth faltor-2 （IGF-2） and the clinical pathology in cervical cancer.Methods IGF-2 were measured with immunhistchemical technique in 50 cases of invasive carcinoma of cervix（SCC）,30 cases of cervical intraepithelial neoplasm （CIN） and 15 cases of normal cervical epithelium （NCE）.The expression of IGF-2 and related clinical pathological factors were analyzed.Results The positive expression ratios of IGF-2 were 0.00%（0/15）,43.33%（13/30） and 74.00% （37/50）,respectively.IGF-2 expression increased significantly from NCE,CIN to SCC （P〈0.05）.The differences between any of the two groups were significant（P〈0.05）.IGF-2 expression were significantly different in different degree of pelviclymph node metastasis,histological grade and stroma infiltration （χ^2=8.698,5.162 and 4.278,respectively,P〈0.05）.IGF-2 expression was correlated positively with lymphatic metastasis and the degree of stroma infiltration （r=0.361 and 0.723,respectively,P〈0.01）,but not with patients age and FIGO staging（χ^2=0.435and 0.631,P〉0.05）.Conclusions The overexpression of IGF-2 in cervical cancer tissue is correlated with the pathogenesis,development and metastasis of cervical cancer,and IGF-2 is a valuable biomarker for cervical cancer.
出处
《中国综合临床》
2010年第4期386-388,共3页
Clinical Medicine of China
基金
皖南医学院中青年科研基金项目（WK200608AF）
