高血压微量白蛋白尿与血肌酐和血尿酸的相关性分析

Analysis of Relationship of Microalbuminuria with Serum Creatinine and Uric Acid in Hypertension Patients

目的:探讨非糖尿病高血压患者微量白蛋白尿与肾功能状况相关性。方法:原发性高血压患者99例,尿常规检查尿蛋白阴性,用微量白蛋白尿试纸条(Micral-testⅡ)测定微量白蛋白尿,0 mg/L和20mg/L为A组,50 mg/L和100 mg/L为B组;分别比较两组之间的年龄、性别、BMI、收缩压、舒张压、血糖、胆固醇、血肌酐、血尿酸等相关因素进行对比分析;对以上变量与尿微量蛋白水平进行Logistic回归分析。结果:两组之间的血肌酐水平分别是(78.98±18.09)μmol/L和(94.84±15.80)μmol/L(P=0.006);血尿酸水平分别是(308.29±76.87)μmol/L和(378.07±85.01)μmol/L(P=0.006);回归分析结果微量白蛋白尿水平与血肌酐正相关(P=0.041),与血尿酸正相关(P=0.001)。结论:在非糖尿病高血压患者中微量白蛋白尿与血肌酐、血尿酸水平正相关;尿的微量白蛋白尿增多预示早期肾脏损害。

Objective：To study the correlation between microalbuminuria and renal function in patients with hypertension and non-diabetes.Method：Microalbuminuria had been examinated by Micral-test Ⅱ in 99 patients of essential hypertension with albuminuria negative,which are divided into two groups according to the level of microalbuminuria that is 0 mg/L and 20 mg/L in group A,50 mg/L and 100 mg/L in group B.The data of age、 sex、 BMI、 systolic pressure、diastolic pressure、 glucose level、cholesterol、serum creatinine and uric acid are compared within the two groups;Logistic regression analysis was made between microalbuminuria and these data.Results：The levels of serum creatinine in two groups are（78.98±18.09） μmol/L and（94.84±15.80） μmol/L（P=0.006）.The levels of serum uric acid in two groups are（308.29±76.87） μmol/L and（378.07±85.01） μmol/L（P=0.006）;Logistic regression analysis indicates positive correlation between microalbuminuria and serum creatinie （P=0.041） and uric acid（P=0.001）. Conclusion：Microalbuminuria is positive correlation with serum creatinine as well as uric acid in patients with hypertension and non-diabetes;The high microalbuminuria demonstrates early renal impairment.