4Yoshino T,Nisijima K,Shioda K,et al.Perospirone,a novel atypical antipsychotic drug,potentiates fluoxetine-induced increases in dopamine levels via multireceptor actions in the rat medial prefrontal cortex[J].Neurosci Lett,2004,1:16-21.
5Mizuno Y,Komuro S,Kanamaru H.D.istribution of perospirone to melanin in pigmented rats[J].EurJDrug Metabol Pharm Acokinet,2003,28:73-79.
6Shimakura J,TaniN,Mizuno Y,et al.In vitro drug-drug interactions with perosp-irone and concomitantly administered drugs in human liver microsomes[J].EurJ Drug Metabolism Pharmacokinet,2003,28:67-72.
2TAKAHASHI Y, KUSUMI I, ISHIKANE T, et al. In vivo occupation of dopamine DI ,D2 and serotonin 2A receptors by novel antipsychotic drug, SM-9018 and its metabolite, in rat brain[J].Neural Transm, 1998,105(2-3) : 181-191.
3OHNO Y. Pharmacological characteristics of perospirone hydrochloride, a novel antipsychotic agent[J]. Nippon Yakurigaku Zasshi ,2000,116(4) :225-231.
4SHIWA T,AMANO T, MATSUBAYASHI H, et al. Perospirone,a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HTIA receptor[J]. Pharmacol Sci ,2003,93 ( 1 ) : 114-117.
5IWAKAWA M, TERAO T,SOYA A, et al. A novel antipsychotic, perospirone, has antiserotonergic and antidopaminergie effects in human brain: findings from neuroendocrine challenge tests[J].Psychopharmacology, 2004,176 (3 -4 ) : 407-411.
6KAZUTOYO I, SHIN I, AKINORI U, et al. Phase I study of perospirone HCL (SM-9018)[J]. Clinical Report,1997,31 (6):188.
7YASUI-FURUKORI N, FURUKORI H, NAKAGAMI T, et al.Steady-state pharmacokinetics of a new antipsychotic agent perospirnoe and its active metabolite, and its relationship with prolactin response[J]. Ther Drug Monit, 2004,26(4):361-365.
8KITAMURA A, MIZUNO Y, NATSUI K, et al. Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone[J]. Biopharm Drug Dispos, 2005,26 (2) :59-65.
9SHIMAKURA J, TANI N, MIZUNO Y, et al. In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes[J]. Eur J Drug Metab Pharmacokinet ,2003,28( 1 ) :67-72.
10ONRUST SV, McCLELLAN K. Perospirone[J]. CNS Drugs,2001,15(4) :329-337.
4Montejo AL. Prolactin awareness: all essential consideration for physical health in schizophrenia. Eur Neuropsychopharmacol, 2008, 18 Suppl 2: S108-S114.
5Vohora D. Atypical antipsyehotie drugs : current issues of safety and effieaw in the management of schizophrenia. Curr Opin Investig Drugs,2007,8(7) :531-538.