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用于动物疫苗注射的无针注射系统的设计 被引量:1

System Design of a Needle-free Injector for Animal Vaccination
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摘要 设计了一种以弹簧为动力、可以连续吸药及注射的无针注射系统,影响无针注射质量的主要系统参数有喷孔直径、药物注射剂量、活塞(安瓿)直径、推射力等。喷射穿刺能力与注射完全度是对动物疫苗进行无针注射质量评价的重要指标,与喷射最大压力和喷射功率相关。给出了在给定系统参数情况下预测喷射压力与喷射功率的物理模型,并用实验验证了模型的正确性。最后通过计算给出了确定系统参数的一个实例。 A spring-powered jet injector was designed for animal vaccine injection.It has the feature of continuous drug delivery and injection.Several parameters are critical to the injection quality,such as nozzle diameter,volume of drug delivered,ampoule diameter,and jetting force.As two important factors to evaluate the injection quality,the injection pressure determines whether the jet can erode and penetrate into the skin,and the jet power effectively describes the injection completeness.A physical model was presented to predict the injection pressure and jet power with given system parameters.The model was validated by experimental results.Finally,an example was given to determine the system variables through calculation.
作者 陈凯 周华
出处 《中国机械工程》 EI CAS CSCD 北大核心 2010年第10期1231-1234,共4页 China Mechanical Engineering
基金 国家自然科学基金资助项目(50775059) "十一五"国家科技支撑计划资助重大项目(2007BAI07A06)
关键词 无针注射 喷射 滞止压强 疫苗 needle-free injection jet stagnation pressure vaccine
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参考文献8

  • 1Willson P. Novel Vaccine Delivery Technology[J]. Advances in Pork Production, 2005,16 : 219-224.
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二级参考文献6

  • 1Mitragotri S. Current status and future prospects of needle-free liquid jet injectors[ J]. Nature Reviews, Drug Discovery, 2006, 5 : 543 - 548.
  • 2Schramm-Baxter J, Katrencik J, Mitragotri S. Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power[ J]. Journal of Control Release, 2004, 97: 527 - 535.
  • 3Shergold OA, Fleck NA, King TS. The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection [ J ]. Journal of Biomechanics, 2006, 39 (14) : 2593 -2602.
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  • 6周华,陈凯,吕永桂.一种液体喷射注射系统的设计与检测[J].机械设计与研究,2009,25(2):116-120. 被引量:4

共引文献6

同被引文献14

  • 1金京.无针安全注射器的设计[J].生物医学工程研究,2007,26(3):297-298. 被引量:8
  • 2Hans - Peter Haar, Wiesloch George, Bevan Kirby Meacham, et al. Ncedleless hypodermic injection system, application device and medication cartridge therefor. US 6986754 B2.
  • 3肖汉,肖治,栾苏泉.连续无针注射器:中国,201603206U[P].
  • 4陈凯.一种用于动物连续注射的无针注射系统:中国,CNl01554498B[P].
  • 5王孝军.兽用无针注射器:中国,CN101428159A[P].
  • 6王军喜.电磁式无针自动注射器:中国,CN201375732Y[P].
  • 7陈凯.电磁力驱动的连续无针注射系统:中国CN101690834B[P].
  • 8王义文,蔺勇智,沈玉辉,等.电动式可调节剂量自动无针注射器:中国,CN201744024U[P].
  • 9黄晶,赵纯亮,陈洪,等.激光驱动无针注射装置:中国,CN201453778U[P].
  • 10陈凯.无针注射器:中国,CN2933434Y[P].

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