甘精胰岛素联合阿卡波糖治疗新诊断老年2型糖尿病疗效观察

Clinical observation on insulin glargine combined with acarbose treating patients with newly diagnosed type 2 diabetes mellitus

目的:比较使用甘精胰岛素联合阿卡波糖与使用预混人胰岛素治疗老年2型糖尿病的疗效和低血糖风险。方法:将60例新诊断住院的老年2型糖尿病患者随机分为甘精胰岛素组(A组)和预混人胰岛素组(B组)。A组采用甘精胰岛素联合阿卡波糖治疗,B组采用预混人胰岛素治疗。观察治疗后2组血糖达标的时间、胰岛素日用量、低血糖发生率。结果:2组在血糖达标时间上差异无显著性,A组胰岛素日用量、低血糖发生率均显著低于B组(P<0.01)。结论:甘精胰岛素联合阿卡波糖治疗老年2型糖尿病安全、有效,方法简单易行。

OBJECTIVE To study the curative effect and hypoglycemia danger of insulin glargine combined with aearbose and biosynthetic human insulin treating patients with newly diagnosed type 2 diabetes metlitus. METHODS Sixty cases of type 2 diabetic patients taking insulin glargine（A group） and biosynthetic human insulin（B group） at random. The 2 groups were compared in the time to reach the target BG, insulin quantity and the incident rate of the hypoglycemia after treatment. RE- SULTS The 2 groups at the time to reach the target BG were not appeared to be significant difference, the incidence rate of hy poglycemia and the requirement of insulin in glargine group were obviously lower than B group（P〈0. 01）. CONCLUSION It is more effective and safer for diabetic patients to use insulin glargine combined with acarbose to decrease BG.