布托啡诺对全麻患者罗库溴铵药效的影响

Effect of Butorphanol on rocuronium-induced neuromuscular block during general anesthesia

目的研究布托啡诺对全麻患者罗库溴铵（ROC）肌松效应的影响。方法 40例妇科全麻择期手术患者,年龄20~60岁,ASA为Ⅰ~Ⅱ级,随机分成两组（n=20）：布托啡诺复合异丙酚组（B组）,芬太尼、瑞芬太尼复合异丙酚组（R组）。两组患者诱导分别采用静脉推注布托啡诺0.02 mg/kg、异丙酚2~5 mg/kg和芬太尼2 mg/kg、异丙酚2~5 mg/kg。静脉注射ROC 0.6 mg/kg后,观察并记录两组ROC起效时间、维持时间、恢复指数。结果两组间年龄、性别等一般资料比较无显著差异,B组ROC起效时间为（78.2±18.9）s、维持时间为（31.2±7.9）min、恢复指数为（10.0±4.1）min,R组ROC起效时间为（80.0±20.1）s、维持时间为（28.9±11.8）min、恢复指数为（10.4±3.8）min。两组ROC起效时间、维持时间和恢复指数比较差异也无统计学差异（P〉0.05）。结论布托啡诺对罗库溴铵的肌松效应无影响。

Objective： To evaluate the effect of Butorphanol on the rocuronium-induced neuromuscular block during general anesthesia.Methods： Forty ASA Ⅰor Ⅱ patients undergoing gynecologic surgery under general anesthesia were randomly divided into 2 groups（n=20）：Butorphanol ＋propofol（B）group and fentanil ＋remifentanil ＋propofol（R）group.The two groups were respectively induced and maintained with Butorphanol,propofol and the TCI of remifentanil（target plasma concentration at 4 ng/ml）combined with propofol.Rocuronium 0.6 mg/kg was given intravenously to facilitate tracheal intubation.The onset time,the duration of neuromuscular blockade and the recovery index were recorded.Results： The onset time of neuromuscular block was from 76 to 82 seconds between the two groups.There was no significant difference in the above parameters between the two groups.Conclusion： Butorphanol has no effect on rocuronium induced neuromuscular block.