摘要
目的探讨手足口病(hand,foot and mouth disease,HFMD)患儿外周血IL-6、IL-10、TNF-α的浓度水平,及其在HFMD发病机制中的作用。方法用ELISA双抗体夹心法测定17例HFMD患儿及同期17例健康体检儿童血清IL-6、IL-10、TNF-α的含量。结果 HFMD患儿血清IL-6和TNF-α水平明显高于健康对照组(P<0.01),IL-10水平与健康对照组比较无显著性差异(P>0.05)。结论 IL-6和TNF-α参与了手足口病发病的病理生理过程,可以作为HFMD临床诊断的检测指标。
Objective : To evaluate the concentrations of peripheral blood interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α in the serum hand foot and mouth disease(HFMD) children and their effects on the pathogenesis of HFMD. Methods: The serum levels of IL-6, IL-10,TNF-α in 17 cases of HFMD children and 17 cases of healthy controls were measured by ELISA methods. Results: The serum levels of IL-6, TNF-α in HFMD patients were significantly higher than those in healthy controls (P 〈 0. 01 ). The serum levels of IL-10 in HFMD patients and healthy controls had no significant change(P 〉 0.05). Conclusion: IL-6, TNF-α might participate in the pathogenesis of HFMD. The serum levels of IL-6, TNF-α can be the criteria for clinical diagnosis in HFMD patients.
出处
《泰山医学院学报》
CAS
2010年第4期292-293,共2页
Journal of Taishan Medical College