阿奇霉素治疗女性生殖道解脲支原体感染的临床观察

Clinlical study on treatment of ureaplasma urealyticum infection in female genitalia with azithromycin

目的探讨治疗女性生殖道解脲支原体(UU)感染的有效方法。方法将确诊为生殖道解脲支原体感染的女性患者共120例,随机分成3组,每组40例。A组口服阿奇霉素,每天1次,每次0.5g,连用7d;B组静脉滴注阿奇霉素,每天1次,每次0.5g,连用7d;C组静脉滴注阿奇霉素,每天1次,每次0.5g,连用3d,停药4d。以上均为一个疗程的治疗。结果 A、B、C三组一个疗程后的UU转阴率依次为:55.0%、77.5%、72.5%;两个疗程后的UU转阴率依次为:75.0%、95.0%、92.5%。三组复发率分别为:36.7%、15.8%、13.5%,不良反应率为:12.5%、15.0%、12.5%。结论静脉滴注阿奇霉素治疗女性生殖道解脲支原体感染,可采用"连用3d,而后停用4d"的序贯疗法,连用两个疗程效果较好。

Objective To assess the effective method for treating ureaplasma urealyticum （UU） infection in female genitalia.Methods One hundred and twenty cases diagnosed as UU infection in female genitalia were randomly allocated into three groups,40 cases in each group.Patients in group A were treated with azithromycin o.5g q.d po for 7 days,patients in group B were treated with azithromycin 0.5g in 5% glucose solution iv gt for 7 days and patients in group C were treated with azithromycin 0.5g in 5% glucose solution iv gt for 3 days,then they were stopped for 4 days.Each therapeutic course was 7 days.Results The successful rates of these three groups were 55.0%,77.5% and 72.5% respectively after first course of treatment,and the successful rates for second course were 75.0%,95.0% and 92.5% respectively.Their relapse rates were 36.7%,15.8% and 13.5% respectively,while their rates for side-effects were 12.5%,15.0% and 12.5% respectively.Conclusion Azithromycin is given intravenously for 3 days,then stopped for 4 days.Totally 2 courses are optimal for treatment of UU Infection in female genitalia.