两种方法治疗2型糖尿病合并高血压的疗效和有效性分析

Analysis of Curative Effect and Effective in Type 2 Diabetes with Hypertension by Two Ways Treatment

目的:探讨两种方法治疗2型糖尿病合并高血压的疗效和有效性。方法:80例2型糖尿病合并高血压患者随机分成常规治疗组(对照组)40例;常规治疗+罗格列酮组(试验组)40例,观察治疗前后两组患者收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、餐后2 h血糖(PBG)、空腹血浆胰岛素(FINS)、餐后2 h血浆胰岛素(PINS)、胰岛素敏感指数(ISI)、和胰岛素抵抗指数(IR)水平,共观察16周。结果:用药16周后,试验组降血压的总有效41例(91.1%)明显高于对照组28例(62.2%)(x^2=3.41,P<0.05);试验组治疗后SBP、DBP、ISI、HOMA-IR、FINS和 PINS较治疗前有显著性差异(t=2.123,t=2.241,t=2.278,P<0.05;t=2.844,t=2.886,t=2.741,P<0.01);试验组治疗后SBP、DBP、ISI、HOMA-IR、FINS和PINS较对照组有显著性差异(t=2.1813,t=2.251,t=2.234,t=2.298,P<0.05;t=2.791,t=2.813,P<0.01);试验组和对照组的不良反应的发生率分别为18.45%和15.79%,组间比较差异无统计学意义(x^2=2.87,P>0.05)。结论:罗格列酮能提高胰岛素敏感指数,具有降低血压的作用。

Objective：To explore the curative effect and effective in type 2 diabetes with hypertension by two ways treatment. Methods：80 patients with type 2 diabetic with hypertension were randomly divided into conven-tional therapy group（Control group）40 cases;Conventional therapy＋rosiglitazone group（Eexperimental group） 40 cases;The indicators of systolic blood pressure（SBP）, diastolic blood pressure（DBP）, fasting blood glucose（FBG）, postprandial 2h blood glucose（PBG）, fasting plasma insulin（FINS）, postprandial 2h plasma insulin （PINS）, insulin sensitivity index （ISI）and insulin resistance index （IR）were observed in in type 2 diabetes with hypertension. Results：The total effective in Eexperimental group 41 cases（91.1%）were significantly higher than that control group 28 cases （62.2%）,（Х^2=3.4 1,P〈0.05）;The indicators of SBP, DBP, ISI,HOMA-IR,FINS,and PINS were significantly difference after treatment than that before treatment（t =2.123,t=2.241.t=2.278,P〈0.05;t=-2.844,t=2.886,t=2.741,P〈0.01）;The indicators of SBP, DBP,ISI,HOMA-IR,FINS,and PINS in Eexperimental group after treatment were significantly difference in control group（t=2.181.t=2.251,t=-2.234,t=-2.298,P〈0.05;t=2.791,t=2.813,P〈0.01）;The rates of adverse reaction in experimental group and control group were 18.45% and 15.79%,were no significant difference （Х^2=2.87,P〉0.05）. Coneluslon：Rosiglitazone increased insulin sensitivity index,with lower blood pressure effect.