机械通气治疗新生儿胎粪吸入综合征临床分析

The Clinical Analysis about Mechanical Ventilation in the Treatment of Neonatal Meconium Aspiration Syndrome

目的:探讨常规机械通气和保护性机械通气对新生儿胎粪吸入综合征(MAS)的治疗效果。方法:将我院收治的42例新生儿胎粪吸入综合征患者经气管插管应用外源性肺表面活性物质(PS)(180～200)mg/kg,随机分为两组,治疗组21例采用保护性机械通气治疗,对照组21例采用常规机械通气治疗。分别观察两组患儿临床症状改善情况,并监测24h内PaO_2、PaCO_2、氧合指数(OI),比较两组患儿的住院时间。结果:保护性通气组患儿的治愈率明显高于常规机械通气组,且并发症较少,住院时间短。在治疗监测的24h内治疗组各个时点OI显著低于对照组。结论:经治疗两组患儿肺的氧合功能均明显提高,但保护性机械通气组的效果优于常规机械通气组,可明显提高MAS的疗效,且降低并发症。

Objective：To discuss the therapeutic effect of mechanical ventilation and protective mechanical ventilation on the neonatal MAS.Methods：My hospital admitted 42 cases of neonatal MAS with tracheal intubation through the application of exogenous PS（180-200）mg/ kg,they were randomly divided into two groups,treatment group 21 cases use of protectivemechanical ventilation,the control group 21 cases with conventional mechanical ventilation.Two groups of children with clinical symptoms were observed to improve the situation and to monitor the 24h in PaO2,PaCO2,OI,compared two groups of children with ve ventilation group cure rate in children was significantly higher than conventional mechanical ventilation group,and fewer complications,shorter hospital stay,24h in the treatment of monitoring at various points within the treatment group OI was significantly lower than the control group.Conclusion：After treatment in children with Jung oxygenation function of the two groups were significantly increased,but the protective effect of mechanical ventilation group is superior to conventional mechanical ventilation group,it can obviously improve the efficacy of MAS,and reduce complications.