复方阿嗪米特治疗老年患者消化不良的疗效观察

The Effect of Compound Azintamide on Dyspepsia Symptoms in the Elderly

目的:观察复方阿嗪米特肠溶片治疗老年患者消化不良的疗效和安全性。方法:将消化内科门诊130例年龄≥60岁的消化不良患者,随机分为治疗组(A组)、对照组(B组),分别为70例和60例,治疗组给予复方阿嗪米特肠溶片治疗(2片/次,3次/d)2周,观察治疗前后上腹胀、上腹部不适、食欲不振的症状积分变化,计算有效率,同时观察记录不良事件。结果:与对照组相比,治疗组治疗2周后各消化不良症状积分均小于对照组,症状积分改善率均显著高于对照组(P<0.01),无严重不良反应发生。结论:复方阿嗪米特肠溶片可显著改善老年人的消化不良症状,且具有良好的安全性。

Objective：To investigate the efficacy and safety of compound azintamide on dyspepsia symptoms in the elderly.Methods： 130 patients（age≥60）with dyspepsia were divided into two groups randomly.The treatment group（n=70） received compound azintamide.Two tablets of compound azintamide were administered orally following a meal,tid for 2 weeks. The changes of symptoms score of abdominal distention, abdominal discomfort, poor appetite and effective rate as well as adverse events were recorded.Results：Symptom scores were significantly decreased after 2 weeks of compound azintamide（P〈0.01）.The effective rate of symptoms was more significant in the treatment group.There were no side effects in any of the patients during the treatment.Conclusion：Compound azintamide showed effective and safety in treatment of elderly patients with dyspepsia symptoms.